Quality of Life and Health-Care Resource Utilization Among Children with Primary Immunodeficiency Receiving Home Treatment with Subcutaneous Human Immunoglobulin
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- Fasth, A. & Nyström, J. J Clin Immunol (2008) 28: 370. doi:10.1007/s10875-008-9180-9
Among patients with antibody deficiency, patient-reported outcomes are important for choosing between equally effective treatment regimens.
Patients and Methods
Twelve children (1.7–17.1 years) with primary immunodeficiency were switched from hospital-based intravenous IgG treatment to home treatment with subcutaneous IgG. Quality of life (Child Health Questionnaire) and health-care resource utilization were assessed at baseline and after 3 and 6 months.
From the parents’ perspective, significant improvements were seen after 6 months for mental health (median difference; 95% confidence interval, 15.0; 0.0, 22.5); change in health (1.0; 0.0, 2.0); and family activities (12.5; 2.1, 25.0). From the children’s’ perspective, significant improvements were seen for role/social limitations-emotional at 3 (22.2; 11.1, 33.3) and 6 months (22.2; 11.1, 66.7) and global health at 6 months (35.0; 15.0, 55.0). There were no significant improvements in other concepts. Subcutaneous IgG treatment significantly reduced absence days, days spent on hospital/physician visits, and health-care-related expenses.
Switching to home-based subcutaneous IgG treatment led to significant improvements in quality of life and substantial cost savings.