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Journal of Clinical Immunology

, Volume 27, Issue 4, pp 347–362 | Cite as

Host Innate Immune Response to Mycobacterium tuberculosis

  • Kamlesh Bhatt
  • Padmini SalgameEmail author
Article

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-γ-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

KEY WORDS

Mycobaterium tuberculosis innate immunity TLR2 dendritic cells macrophages 

Notes

ACKNOWLEDGMENTS

This work was supported in part by the NIH grants AI-49778 and AI-55377 to PS.

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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Medicine, Centre for Emerging PathogensUMDNJ-New Jersey Medical SchoolNewarkUSA

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