Journal of Clinical Immunology

, Volume 26, Issue 1, pp 65–72

Health-Related Quality of Life and Treatment Satisfaction in North American Patients with Primary Immunedeficiency Diseases Receiving Subcutaneous IgG Self-Infusions at Home

  • Uwe Nicolay
  • Peter Kiessling
  • Melvin Berger
  • Sudhir Gupta
  • Leman Yel
  • Chaim M. Roifman
  • Ann Gardulf
  • Florian Eichmann
  • Stefan Haag
  • Cordula Massion
  • Hans D. Ochs
Article

Abstract

The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patients treated with IVIG at the hospital/doctor's office (Group A) or at home (Group B) before the study started. Forty-four adult North American PIDD patients were included in the study, 28 patients in Group A and 16 in Group B. Patients in Group A reported significantly less limitations with their work/daily activities, a significantly improved vitality, and better general health. Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy.

Keywords

Primary immunedeficiency disease subcutaneous IgG therapy intravenous IgG therapy home-therapy quality of life treatment satisfaction 

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Uwe Nicolay
    • 1
    • 9
  • Peter Kiessling
    • 2
  • Melvin Berger
    • 3
  • Sudhir Gupta
    • 4
  • Leman Yel
    • 4
  • Chaim M. Roifman
    • 5
  • Ann Gardulf
    • 1
  • Florian Eichmann
    • 6
  • Stefan Haag
    • 2
  • Cordula Massion
    • 7
  • Hans D. Ochs
    • 8
  1. 1.Section of Clinical Immunology, Department of Laboratory MedicineKarolinska Institutet at Karolinska University HospitalStockholmSweden
  2. 2.Clinical Research, ZLB Behring GmbHMarburgGermany
  3. 3.Division of Allergy, Immunology and RheumatologyRainbow Babies and Children's HospitalClevelandOhio
  4. 4.Division of Basic and Clinical Immunology, Department of MedicineUniversity of CaliforniaIrvine
  5. 5.The Hospital for Sick ChildrenTorontoCanada
  6. 6.Kendle International Inc.MunichGermany
  7. 7.Department of BiostatisticsAccovion GmbHMarburgGermany
  8. 8.Department of PediatricsUniversity of WashingtonSeattle
  9. 9.M96, Section of Clinical Immunology, Department of Laboratory MedicineKarolinska Institutet at Karolinska University HospitalStockholmSweden

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