Journal of Clinical Immunology

, Volume 26, Issue 1, pp 40–54 | Cite as

HIV-1-Specific CD4+ T Cell Responses in Chronically HIV-1 Infected Blippers on Antiretroviral Therapy in Relation to Viral Replication Following Treatment Interruption

  • Emmanouil Papasavvas
  • Jay R. Kostman
  • Brian Thiel
  • Maxwell Pistilli
  • Agnieszka Mackiewicz
  • Andrea Foulkes
  • Robert Gross
  • Kimberly A. Jordan
  • Douglas F. Nixon
  • Robert Grant
  • Jean-francois Poulin
  • Joseph M. Mccune
  • Karam Mounzer
  • Luis J. Montaner
Article

Abstract

The impact of transient viral load blips on anti-HIV-1 immune responses and on HIV-1 rebound following treatment interruption (TI) is not known. Clinical and immunological parameters were measured during 40 weeks of antiretroviral therapy (ART) and following TI in an observational cohort of 16 chronically HIV-1-infected subjects with or without observed viral load blips during ART. During therapy, blips in seven subjects were associated with higher anti-HIV-1 (p24) CD4+ T cell lymphoproliferative responses (p = 0.04), without a significant difference in T cell activation or total anti-HIV-1 CD8+ T cell interferon-γ (IFN-γ) responses when compared to nine matched non-blippers. Therapy interruption resulted in a significantly higher viral rebound in blippers by 8 week despite retention of higher lymphoproliferative p24 responses (p = 0.01) and a rise in CD3+ T cell activation (p = 0.04) and anti-HIV-1 CD8+ T cell responses in blippers by week 4 when compared to non-blippers. Past week 4 of interruption, therapy re-initiation criteria were also met by a higher frequency in blippers by week 14 (p < 0.04) with no difference between groups by week 24. These data support that blippers have higher anti-HIV lymphoproliferative responses while on ART but experience equal to higher viral rebound as compared to matched non-blippers upon TI.

Keywords

Blips HIV treatment interruption CD4+ T cell responses 

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Emmanouil Papasavvas
    • 1
  • Jay R. Kostman
    • 2
    • 3
  • Brian Thiel
    • 1
  • Maxwell Pistilli
    • 1
  • Agnieszka Mackiewicz
    • 1
  • Andrea Foulkes
    • 4
  • Robert Gross
    • 3
    • 4
  • Kimberly A. Jordan
    • 5
  • Douglas F. Nixon
    • 5
    • 6
  • Robert Grant
    • 5
    • 6
  • Jean-francois Poulin
    • 5
  • Joseph M. Mccune
    • 5
    • 6
  • Karam Mounzer
    • 2
  • Luis J. Montaner
    • 2
    • 7
  1. 1.The Wistar InstitutePhiladelphia
  2. 2.Philadelphia Field Initiating Group for HIV-1 TrialsPhiladelphia
  3. 3.Division of Infectious DiseasesUniversity of PennsylvaniaPhiladelphia
  4. 4.Center for Clinical Epidemiology and BiostatisticsUniversity of PennsylvaniaPhiladelphia
  5. 5.The Gladstone Institute of Virology and ImmunologyUniversity of CaliforniaSan Francisco
  6. 6.Department of MedicineUniversity of CaliforniaSan Francisco
  7. 7.the Wistar InstitutePhiladelphia

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