NKG2D in NK and T Cell-Mediated Immunity
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- Ogasawara, K. & Lanier, L.L. J Clin Immunol (2005) 25: 534. doi:10.1007/s10875-005-8786-4
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One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.