Journal of Clinical Immunology

, Volume 25, Issue 6, pp 503–510 | Cite as

Innate Sensors of Microbial Infection

  • Diana C. HargreavesEmail author
  • Ruslan Medzhitov


The innate immune system utilizes multiple families of pattern-recognition receptors (PRRs) to protect the host from infection. Each of these families contributes certain elements to the complement of innate effector functions that is elicited during an infection. Here we review the families of PRRs and explore examples of their cooperativity.

Key Words

Pattern Recognition Receptor Toll-like receptor NOD1 and NOD2 RIG-I and MDA-5 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.HHMI and Section of ImmunobiologyYale University School of MedicineNew Haven

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