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Journal of Clinical Immunology

, Volume 25, Issue 2, pp 134–141 | Cite as

Reduced Type 1 and Type 2 Cytokines in Antiviral Memory T Helper Function Among Women Coinfected with HIV and HCV

  • Maria C. VillacresEmail author
  • Oana Literat
  • Marina Degiacomo
  • Wenbo Du
  • Corinna La Rosa
  • Don J. Diamond
  • Andrea Kovacs
Article

Abstract

Bias in cytokine responses has been proposed as a contributing mechanism to pathogenesis in persistent HIV or hepatitis C virus (HCV) infections. We investigated whether coinfection with HCV modifies the profile of antigen-specific cytokine secretion in women persistently infected with HIV compared to women with single HIV or HCV infection. The T helper response to HIV, HCV and cytomegalovirus (CMV) as a positive viral control was dominated by type 1 cytokines (interleukin- [IL] 2, interferon- [IFN] γ and tumor necrosis factor- [TNF] α), with IFN-γ as the most abundantly secreted. IL-4, IL-5 and IL-10 were low in healthy controls and patients. Robust CMV-specific responses contrasted with curtailed HCV-specific responses in HCV-infected women. The overall anti-viral profile was dominated by Th1 cytokines even in coinfected women but both type 1 and type 2 responses were reduced in HIV-infected women and more extensively in women with HCV/HIV coinfection.

Keywords

T helper cells cytokines infectious diseases hepatitis C virus HIV 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Maria C. Villacres
    • 1
    • 3
    Email author
  • Oana Literat
    • 1
  • Marina Degiacomo
    • 1
  • Wenbo Du
    • 1
  • Corinna La Rosa
    • 2
  • Don J. Diamond
    • 2
  • Andrea Kovacs
    • 1
  1. 1.Maternal, Child and Adolescent Center for Infectious Diseases and Virology, Keck School of MedicineUniversity of Southern CaliforniaLos Angeles
  2. 2.Laboratory of Vaccine ResearchBeckman Research Institute of the City of HopeDuarte
  3. 3.Department of Pediatrics, Keck School of MedicineUniversity of Southern CaliforniaLos Angeles

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