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Journal of Chemical Crystallography

, Volume 41, Issue 8, pp 1114–1119 | Cite as

Two Novel Potential Anticonvulsant Salts of 5-Amino-2-Sulfonamide-1,3,4-Thiadiazole

  • Jorge R. A. Díaz
  • Gerardo E. Camí
  • Malva L. González
  • José C. Pedregosa
  • Daniel R. VegaEmail author
Original Paper

Abstract

Two crystal structures of sulfonamide salts were studied by X-Ray diffraction. The compound C2H5N4O2S2 +·H2O·Cl (I), (Hats·H2O·Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P212121, with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) Å and the compound C2H5N4O2S2 +·CH3O3S (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) Å, beta = 99.97(1)°. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl ions and one ring with a graph set R 6 4 (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R 2 2 (8).

Index abstract

Two substituted sulfonamide salts were obtained, the hydrochloride is monohydrate and develops a helix arrangement of alternating water/sulfonamide molecules, meanwhile the mesylate is bonded to sulfonamide molecule determining a ring, with a graph set R 2 2 (8).

Keywords

Sulfonamides Sulfonamide salts Crystal structure 

Notes

Acknowledgments

J.R.A.D. thanks a UNSL fellowship. We thank the financial support of ANPCyT (Project PICT 25459), SECyT-UNSL (Project 7707) and CONICET (PIP Nº 01360/08). We are grateful to S.C.S.I.E. (X-ray section) of University of Valencia for provision of the X-ray crystallographic facilities. J.C.P. is member of CONICET.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jorge R. A. Díaz
    • 1
  • Gerardo E. Camí
    • 1
  • Malva L. González
    • 2
  • José C. Pedregosa
    • 1
  • Daniel R. Vega
    • 3
    Email author
  1. 1.Área de Química General e Inorgánica, “Dr. G. F. Puelles”, Facultad de Química, Bioquímica y FarmaciaUniversidad Nacional de San LuisSan LuisArgentina
  2. 2.S.C.S.I.E. (Unidad de Rayos X)—Facultad de FísicaUniversidad de Valencia,ValenciaSpain
  3. 3.Grupo Materia Condensada, GIyA, GAIyANN, Comisión Nacional de Energía AtómicaSan Martín, Buenos AiresArgentina

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