Journal of Computational Neuroscience

, Volume 20, Issue 1, pp 77–84

Spike propagation in dendrites with stochastic ion channels

Article

Abstract

We investigate the effects of the stochastic nature of ion channels on the faithfulness, precision and reproducibility of electrical signal transmission in weakly active, dendritic membrane under in vitro conditions. The properties of forward and backpropagating action potentials (BPAPs) in the dendritic tree of pyramidal cells are the subject of intense empirical work and theoretical speculation (Larkum et al., 1999; Zhu, 2000; Larkum et al., 2001; Larkum and Zhu, 2002; Schaefer et al., 2003; Williams, 2004; Waters et al., 2005). We numerically simulate the effects of stochastic ion channels on the forward and backward propagation of dendritic spikes in Monte-Carlo simulations on a reconstructed layer 5 pyramidal neuron. We report that in most instances there is little variation in timing or amplitude for a single BPAP, while variable backpropagation can occur for trains of action potentials. Additionally, we find that the generation and forward propagation of dendritic Ca2+ spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing of Ca2+ spikes.

Keywords

temporal precision spike reliability coincidence detection 

Abbreviations

BAC

Backpropagation activated Ca2+ spike

AP

Action potential

BPAP

Backpropagating action potential

ISI

Interstimulus interval

rp

Reference point

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Division of BiologyPasadena
  2. 2.Center for Molecular and Behavioral NeuroscienceRutgers UniversityNewark
  3. 3.Life Sciences Institute and Interdisciplinary Center for Neural ComputationHebrew UniversityJerusalemIsrael

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