Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions
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Thermodynamics is an important driving factor for chemical processes and for life. Earlier work has shown that each cancer has its own molecular signaling network that supports its life cycle and that different cancers have different thermodynamic entropies characterizing their signaling networks. The respective thermodynamic entropies correlate with 5-year survival for each cancer. We now show that by overlaying mRNA transcription data from a specific tumor type onto a human protein–protein interaction network, we can derive the Gibbs free energy for the specific cancer. The Gibbs free energy correlates with 5-year survival (Pearson correlation of –0.7181, p value of 0.0294). Using an expression relating entropy and Gibbs free energy to enthalpy, we derive an empirical relation for cancer network enthalpy. Combining this with previously published results, we now show a complete set of extensive thermodynamic properties and cancer type with 5-year survival.
KeywordsCancer Signaling networks Gibbs free energy Entropy Protein-protein interactions 5-year survival
EAR was partly funded by the Newman Lakka Cancer Foundation, and CSTS Healthcare. JAT acknowledges funding from NSERC, Canadian Breast Cancer Foundation and the Allard Foundation. GLK was funded by NIH NIGMS RO1 GM93050, and philanthropic funds from Newman Lakka Cancer Foundation, Campanelli Foundation, Jack in the Beanstalk Foundation, and Binational Science Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Heath.
EAR conceived the idea. JAT and EAR collaborated on the thermodynamics. JP contributed key chemical physics concepts. GLK contributed cancer biology concepts. All authors contributed to writing the manuscript.
- 1.Rietman, E., Bloemendal, A., Platig, J., Tuszynski, J., Klement, G.L.: Gibbs free energy of protein–protein interactions reflects tumor stage. http://biorxiv.org/content/early/2015/07/13/022491 (2015)
- 2.Paliouras, M., Zaman, N., Lumbroso, R., Kapogeorgakis, L., Beitel, L.K., Wang, E., Trifiro, M.: Dynamic rewiring of the androgen receptor protein interaction network correlates with prostate cancer clinical outcomes. Integr. Biol. (Camb.) 3, 1020–1032 (2011). doi: 10.1039/c1ib00038a CrossRefGoogle Scholar
- 25.Breitkreutz, B.J., Stark, C., Tyers, M.: The GRID: the general repository for interaction datasets. Genome Biol. 3, PREPRINT0013 (2002)Google Scholar
- 26.Maskill, H.: The Physical Basis of Organic Chemistry. Oxford University Press, New York (1986)Google Scholar