Journal of Biological Physics

, Volume 39, Issue 2, pp 301–325

Design rules for nanomedical engineering: from physical virology to the applications of virus-based materials in medicine

  • Amy M. Wen
  • Pooja H. Rambhia
  • Roger H. French
  • Nicole F. Steinmetz
Original Paper


Physical virology seeks to define the principles of physics underlying viral infections, traditionally focusing on the fundamental processes governing virus assembly, maturation, and disassembly. A detailed understanding of virus structure and assembly has facilitated the development and analysis of virus-based materials for medical applications. In this Physical Virology review article, we discuss the recent developments in nanomedicine that help us to understand how physical properties affect the in vivo fate and clinical impact of (virus-based) nanoparticles. We summarize and discuss the design rules that need to be considered for the successful development and translation of virus-based nanomaterials from bench to bedside.


Design rules Viral nanoparticles Physical virology Nanotechnology Nanomedicine Drug delivery Long range interactions 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Amy M. Wen
    • 1
  • Pooja H. Rambhia
    • 3
  • Roger H. French
    • 4
  • Nicole F. Steinmetz
    • 2
    • 4
    • 5
  1. 1.Department of Biomedical Engineering, School of EngineeringCase Western Reserve UniversityClevelandUSA
  2. 2.Department of Biomedical Engineering, School of MedicineCase Western Reserve UniversityClevelandUSA
  3. 3.Department of Biochemistry, School of MedicineCase Western Reserve UniversityClevelandUSA
  4. 4.Materials Science and Engineering, School of EngineeringCase Western Reserve UniversityClevelandUSA
  5. 5.Department of Radiology, School of MedicineCase Western Reserve UniversityClevelandUSA

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