Journal of Biological Physics

, Volume 37, Issue 2, pp 185–188 | Cite as

Case for an RNA–prion world: a hypothesis based on conformational diversity

  • Param Priya Singh
  • Anirban Banerji
Short Note


Prions and other misfolded proteins can impart their structure and functions to normal molecules. Based upon a thorough structural assessment of RNA, prions and misfolded proteins, especially from the perspective of conformational diversity, we propose a case for co-existence of these in the pre-biotic world. Analyzing the evolution of physical aspects of biochemical structures, we put forward a case for an RNA–prion pre-biotic world, instead of, merely, the “RNA World”.


Drawbacks of “RNA world” Prions Conformational diversity Coexistence of RNA–prion-misfolded proteins 



One of the authors, Anirban, acknowledges the support from COE-DBT scheme (Government of India).


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Param Priya Singh
    • 1
  • Anirban Banerji
    • 1
  1. 1.Bioinformatics CentreUniversity of PunePuneIndia

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