Journal of Biological Physics

, Volume 37, Issue 3, pp 317–345 | Cite as

Positive feedback loops sustain repeating bursts in neuronal circuits

  • Wolfgang Otto Friesen
  • Olivia J. Mullins
  • Ran Xiao
  • John T. Hackett
Original Paper

Abstract

Voluntary movements in animals are often episodic, with abrupt onset and termination. Elevated neuronal excitation is required to drive the neuronal circuits underlying such movements; however, the mechanisms that sustain this increased excitation are largely unknown. In the medicinal leech, an identified cascade of excitation has been traced from mechanosensory neurons to the swim oscillator circuit. Although this cascade explains the initiation of excitatory drive (and hence swim initiation), it cannot account for the prolonged excitation (10–100 s) that underlies swim episodes. We present results of physiological and theoretical investigations into the mechanisms that maintain swimming activity in the leech. Although intrasegmental mechanisms can prolong stimulus-evoked excitation for more than one second, maintained excitation and sustained swimming activity requires chains of several ganglia. Experimental and modeling studies suggest that mutually excitatory intersegmental interactions can drive bouts of swimming activity in leeches. Our model neuronal circuits, which incorporated mutually excitatory neurons whose activity was limited by impulse adaptation, also replicated the following major experimental findings: (1) swimming can be initiated and terminated by a single neuron, (2) swim duration decreases with experimental reduction in nerve cord length, and (3) swim duration decreases as the interval between swim episodes is reduced.

Keywords

Neuronal circuits Leech Reciprocal excitation Mutual excitation Episodic behavior 

Abbreviations

ADO

Adenosine

BPE

Bursts per episode

DP

Dorsal posterior (nerve)

CNS

Central nervous system

CPG

Central pattern generator

IN

Interneuron

MN

Motoneurons

RCI

Recurrent cyclic inhibition

RE

Reciprocally excitatory

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Wolfgang Otto Friesen
    • 1
    • 2
  • Olivia J. Mullins
    • 1
    • 2
  • Ran Xiao
    • 1
  • John T. Hackett
    • 2
    • 3
  1. 1.Department of BiologyUniversity of VirginiaCharlottesvilleUSA
  2. 2.Neuroscience Graduate ProgramUniversity of VirginiaCharlottesvilleUSA
  3. 3.Department of Molecular Physiology and Biological PhysicsUniversity of VirginiaCharlottesvilleUSA

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