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Journal of Biological Physics

, Volume 35, Issue 4, pp 383–411 | Cite as

Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes

  • Maurizio De Pittà
  • Mati Goldberg
  • Vladislav Volman
  • Hugues Berry
  • Eshel Ben-Jacob
Original Paper

Abstract

Recent years have witnessed an increasing interest in neuron–glia communication. This interest stems from the realization that glia participate in cognitive functions and information processing and are involved in many brain disorders and neurodegenerative diseases. An important process in neuron–glia communications is astrocyte encoding of synaptic information transfer—the modulation of intracellular calcium (Ca2 + ) dynamics in astrocytes in response to synaptic activity. Here, we derive and investigate a concise mathematical model for glutamate-induced astrocytic intracellular Ca2 +  dynamics that captures the essential biochemical features of the regulatory pathway of inositol 1,4,5-trisphosphate (IP3). Starting from the well-known two-variable (intracellular Ca2 +  and inactive IP3 receptors) Li–Rinzel model for calcium-induced calcium release, we incorporate the regulation of IP3 production and phosphorylation. Doing so, we extend it to a three-variable model (which we refer to as the ChI model) that could account for Ca2 +  oscillations with endogenous IP3 metabolism. This ChI model is then further extended into the G-ChI model to include regulation of IP3 production by external glutamate signals. Compared with previous similar models, our three-variable models include a more realistic description of IP3 production and degradation pathways, lumping together their essential nonlinearities within a concise formulation. Using bifurcation analysis and time simulations, we demonstrate the existence of new putative dynamical features. The cross-couplings between IP3 and Ca2 +  pathways endow the system with self-consistent oscillatory properties and favor mixed frequency–amplitude encoding modes over pure amplitude–modulation ones. These and additional results of our model are in general agreement with available experimental data and may have important implications for the role of astrocytes in the synaptic transfer of information.

Keywords

Inositol 1,4,5-trisphosphate metabolism Calcium signaling Pulsating dynamics Information encoding Phase locking 

Notes

Acknowledgements

The authors wish to thank Vladimir Parpura, Giorgio Carmignoto, and Ilyia Bezprozvanny for insightful conversations. V. V. acknowledges the support of the U.S. National Science Foundation I2CAM International Materials Institute Award, Grant DMR-0645461. This research was supported by the Tauber Family Foundation, by the Maguy-Glass Chair in Physics of Complex Systems at Tel Aviv University, by the NSF-sponsored Center for Theoretical Biological Physics (CTBP), grants PHY-0216576 and 0225630, and by the University of California at San Diego.

Supplementary material

10867_2009_9155_Fig1_ESM.gif (23 kb)
Supplementary Figure 1

The product of two Hill functions (a-b) with sufficiently distant midpoints is equivalent to the Hill function with the largest midpoint (c). Namely: Hill(x, K 1) · Hill(x, K 2) ≈ Hill(x, K 2) where K 1<<K 2. Midpoints are marked by vertical dashed lines; K 1: red; K 2: blue. (GIF 22.5KB)

10867_2009_9155_Fig1_ESM.eps (147 kb)
High resolution image file (EPS 146KB)
10867_2009_9155_Fig2_ESM.gif (51 kb)
Supplementary Figure 2

Hill functions of Hill functions (a-b) can also be approximated by Hill functions. (c-d) Hill (Hill(x, K 2), K 1) = (1+K 1)−1. Hill(x, K 1 K 2(1+K 1)−1). In this case the midpoint of the resulting Hill function depends on the specific values of the midpoints of the original Hill functions considered in the composition of the Hill-of-Hill function. (e-h) Hill(x, K 1 · Hill (x, K 2)) = (x + K 2)/(x + K 1 + K 2) = Hill (x, (K 1 + K 2)) + f(x), where f(x) = K 2/(x + K 1 + K 2). Notably, f(x⟶0) = K 2/(K 1 + K 2) whereas f(x⟶∞) ≈ 0, so that the resulting Hill curve is essentially comprised within the interval [K 2/(K 1 + K 2),1). (GIF 50.6KB)

10867_2009_9155_Fig2_ESM.eps (285 kb)
High resolution image file (EPS 284KB)
10867_2009_9155_Fig3_ESM.gif (45 kb)
Supplementary Figure 3

Bifurcation diagrams for a modified ChI model and prototypical sets of (a-c) AM-encoding and (d-f) FM-encoding L-R parameters. The bifurcation diagrams were computed after introduction into the ChI model of the rate of glutamate-dependent IP3 production, v glu , as a free bifurcation parameter, namely \(\bar I = v_{glu} + v_\sigma (C,I) - v_{3K} (C,I) - v_{5P} (I)\). This figure shows that the ChI model can still display oscillations in presence of an external non-specific bias of IP3 production. This is a first suggestion that the corresponding glutamate-dependent G-ChI model may also display oscillations. The parameters are taken from Table 1. (GIF 44.6KB)

10867_2009_9155_Fig3_ESM.eps (191 kb)
High resolution image file (EPS 191KB)

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Maurizio De Pittà
    • 1
  • Mati Goldberg
    • 1
  • Vladislav Volman
    • 2
    • 3
  • Hugues Berry
    • 4
  • Eshel Ben-Jacob
    • 1
    • 2
  1. 1.School of Physics and AstronomyTel Aviv UniversityRamat AvivIsrael
  2. 2.Center for Theoretical Biological PhysicsUCSDLa JollaUSA
  3. 3.Computational Neurobiology LabThe Salk InstituteLa JollaUSA
  4. 4.Project-Team AlchemyINRIA SaclayOrsayFrance

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