Journal of Biological Physics

, 33:331 | Cite as

From Membrane Pores to Aquaporins: 50 Years Measuring Water Fluxes

  • Mario Parisi
  • Ricardo A. Dorr
  • Marcelo Ozu
  • Roxana Toriano
Original Paper


This review focuses on studies of water movement across biological membranes performed over the last 50 years. Different scientific approaches had tried to elucidate such intriguing mechanism, from hypotheses emphasizing the role of the lipid bilayer to the cloning of aquaporins, the ubiquitous proteins described as specific water channels. Pioneering and clarifying biophysical work are reviewed beside results obtained with the help of recent sophisticated techniques, to conclude that great advances in the subject live together with old questions without definitive answers.


Water channels Aquaporins Single file Water diffusion Osmotic permeability Water pathway 


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Mario Parisi
    • 1
  • Ricardo A. Dorr
    • 2
  • Marcelo Ozu
    • 1
  • Roxana Toriano
    • 2
  1. 1.Unidad de BiomembranasUniversidad FavaloroBuenos AiresArgentina
  2. 2.Laboratorio de Biomembranas, Departamento de Fisiología, Facultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

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