Journal of Biological Physics

, Volume 32, Issue 3–4, pp 355–368 | Cite as

The Virtual Ventricular Wall: A Tool for Exploring Cardiac Propagation and Arrhythmogenesis

  • Arun V. Holden
  • Oleg V. Aslanidi
  • Alan P. Benson
  • Richard H. Clayton
  • Graeme Halley
  • Pan Li
  • Wing Chiu Tong
Research Paper

Abstract

Methods for the experimental and clinical investigation of cardiac arrhythmias are limited to inferring propagation within the myocardium, from surface measurements, or from electrodes at a few sites within the cardiac wall. Biophysically and anatomically detailed computational models of cardiac tissues offer a powerful way for studying the electrical propagation processes and arrhythmias within the virtual heart. We use virtual tissues to study and visualise the effects of patho- and physiological conditions, and pharmacological interventions on transmural propagation in the virtual ventricular walls. Class III drug actions are quantitatively explained by changes induced in the transmural dispersion of action potential duration. We illustrate the automated construction of a virtual anisotropic ventricle from Diffusion Tensor MRI for individual hearts, and use it to explore mechanisms leading to ventricular fibrillation. The virtual ventricular wall provides an effective tool for exploring, evaluating and visualising processes during the initiation and maintenance of ventricular arrhythmias.

Key words

cardiac arrhythmias Diffusion Tensor MRI Ventricular fibrillation (VF) ventricular wall virtual tissues 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Arun V. Holden
    • 1
  • Oleg V. Aslanidi
    • 1
  • Alan P. Benson
    • 1
  • Richard H. Clayton
    • 2
  • Graeme Halley
    • 1
  • Pan Li
    • 1
  • Wing Chiu Tong
    • 1
  1. 1.Computational Biology Laboratory, Institute of Membrane and Systems BiologyUniversity of LeedsLeedsUK
  2. 2.Department of Computer ScienceUniversity of SheffieldSheffieldUK

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