Psychosocial factors associated with treatment outcomes in women with obesity and major depressive disorder who received behavioral activation for depression
Behavioral activation is an empirically supported treatment for depression, but much is unknown about factors associated with treatment response. The present study aimed to determine whether baseline levels and subsequent changes in psychosocial factors were associated with improvement in depression in women with comorbid obesity who received behavioral activation treatment for depression and a lifestyle intervention. Multilevel modeling was used to estimate the associations between psychosocial factors and change in depression scores during the first 10 weeks of treatment and associations between changes in psychosocial factors from baseline to 6-month follow-up and change in depression over the same time period. No baseline psychosocial factors were associated with depression improvement during treatment (p = 0.110–0.613). However, greater improvement in hedonic capacity (p = 0.001), environmental reward (p = 0.004), and social impairment (p = 0.012) were associated with greater reductions in depression over 6 months. Findings highlight the differential relationship specific psychosocial factors have with depression treatment outcomes.
KeywordsBehavioral therapy Comorbidity Treatment response Hedonic capacity Environmental reward Social engagement
Partial support for Dr. Waring provided by NIH Grant KL2TR000160 and for Dr. Whited by NIH Grant 5K23HL109620.
Compliance with ethical standards
Conflict of interest
Daniel Kern, Andrew Busch, Kristin L. Schneider, Steven A. Miller, Bradley M. Appelhans, Molly E. Waring, Matthew C. Whited, and Sherry Pagoto declare that they have no conflict of interest.
Human and animal rights and Informed consent
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
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