The influence of exercise training dose on fasting acylated ghrelin concentration in older women
This study investigated if exercise dose affected acylated ghrelin response to exercise training, and how body weight or fat mass changes might affect the responses. Non-obese older women (n = 49) were randomly assigned to 4-month moderate-intensity aerobic exercise of one of two doses (8 or 14 kcal kg−1 body weight weekly). Following exercise training, fasting acylated ghrelin concentrations changed differently between the two groups (p for group × time interaction = 0.050). It decreased in the moderate-dose (Cohen’s d = 0.52, p = 0.019), but did not change in the low-dose exercise group. Adjustment for weight or fat changes did not affect these results. Therefore, exercise training dose can have specific effects on acylated ghrelin that are not dependent on weight or fat loss. However, whether the different acylated ghrelin changes are associated with differing degree of subsequent weight maintenance worth further investigation.
KeywordsGhrelin Exercise training Weight loss Energy balance Older women
This work was supported by the United States National Institutes of Health (Grant Number R00AG031297).
Compliance with ethical standards
Conflict of interest
Kimberly P. Bowyer, James A. Carson, J. Mark Davis and Xuewen Wang declare that they have no conflict of interest.
Human and animal rights and Informed consent
All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all patients for being included in the study.
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