Journal of Behavioral Medicine

, Volume 36, Issue 6, pp 583–590

Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study

  • Christian Hakulinen
  • Markus Jokela
  • Mirka Hintsanen
  • Päivi Merjonen
  • Laura Pulkki-Råback
  • Ilkka Seppälä
  • Leo-Pekka Lyytikäinen
  • Terho Lehtimäki
  • Mika Kähönen
  • Jorma Viikari
  • Olli T. Raitakari
  • Liisa Keltikangas-Järvinen
Article

DOI: 10.1007/s10865-012-9452-y

Cite this article as:
Hakulinen, C., Jokela, M., Hintsanen, M. et al. J Behav Med (2013) 36: 583. doi:10.1007/s10865-012-9452-y

Abstract

The serotonin system has been shown to be involved in the regulation of hostility, anger, and aggressive behavior. Previous molecular genetic studies suggest that the serotonin receptor 1B (HTR1B) rs6296 genotype might have a particular role in these types of behaviors. We examined whether HTR1B is related to hostility, anger, and aggressive behavior phenotypes over a lifespan and whether it modifies the connection between childhood aggressive behavior and adulthood hostility and anger. The participants were 967 women and men from a large population based sample (The Young Finns Study) with a 27-year follow-up. Childhood aggressive behavior was reported by the mother twice when the participants were 3 to 12 years of age. Adulthood hostility and anger were self-reported by the participants between ages 24 and 36. Childhood aggressive behavior predicted adulthood hostility over 27 years. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. Aggressive behavior and hostility might form a life course pattern, and the HTR1B might contribute to a development of this pattern.

Keywords

Hostility Anger Aggression Serotonin HTR1B 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Christian Hakulinen
    • 1
  • Markus Jokela
    • 1
  • Mirka Hintsanen
    • 1
    • 2
  • Päivi Merjonen
    • 1
  • Laura Pulkki-Råback
    • 1
  • Ilkka Seppälä
    • 3
    • 4
  • Leo-Pekka Lyytikäinen
    • 3
    • 4
  • Terho Lehtimäki
    • 3
    • 4
  • Mika Kähönen
    • 4
    • 5
  • Jorma Viikari
    • 6
  • Olli T. Raitakari
    • 7
    • 8
  • Liisa Keltikangas-Järvinen
    • 1
  1. 1.IBS, Unit of Personality, Work and Health PsychologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Helsinki Collegium for Advanced StudiesUniversity of HelsinkiHelsinkiFinland
  3. 3.Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory MedicineTampere University HospitalTampereFinland
  4. 4.Medical SchoolUniversity of TampereTampereFinland
  5. 5.Department of Clinical PhysiologyUniversity of Tampere and Tampere University HospitalTampereFinland
  6. 6.Department of MedicineTurku University HospitalTurkuFinland
  7. 7.Research Centre of Applied and Preventive Cardiovascular MedicineUniversity of TurkuTurkuFinland
  8. 8.Departments of Clinical Physiology and Nuclear MedicineTurku University HospitalTurkuFinland

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