Journal of Behavioral Medicine

, Volume 33, Issue 3, pp 219–227 | Cite as

Treatment adherence in multiple sclerosis: association with emotional status, personality, and cognition

  • Jared M. Bruce
  • Laura M. Hancock
  • Peter Arnett
  • Sharon Lynch
Article

Abstract

The purpose of the present study was to prospectively examine the association between treatment adherence and common neuropsychiatric symptoms in multiple sclerosis (MS). Patients underwent a thorough psychiatric and neuropsychological evaluation at the outset of the study. Patient adherence to disease modifying therapies was then tracked for 8 weeks using self-report, a medication diary, and an electronic monitoring device that recorded needle disposals. Results indicated that MS patients with current mood or anxiety disorders were almost five times as likely as MS patients with no psychiatric diagnosis to exhibit problems adhering to their disease modifying therapies. Poor adherence was also associated with memory difficulties, anxiety, depression, neuroticism, and low conscientiousness. Findings highlight the importance of conducting a thorough psychiatric and neuropsychological evaluation when clinicians suspect poor adherence to disease modifying therapies. Pharmacological or psychotherapeutic treatment of mood/anxiety disorders, use of scheduled reminders, and/or increased organization and structure may lead to improved treatment adherence in MS.

Keywords

Multiple sclerosis Adherence MEMS Cognition Memory Depression Anxiety 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jared M. Bruce
    • 1
  • Laura M. Hancock
    • 1
  • Peter Arnett
    • 2
  • Sharon Lynch
    • 3
  1. 1.Department of PsychologyUniversity of Missouri–Kansas CityKansas CityUSA
  2. 2.Department of PsychologyThe Pennsylvania State UniversityUniversity ParkUSA
  3. 3.Landon Center on AgingUniversity of Kansas Medical CenterKansas CityUSA

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