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Journal of Bioenergetics and Biomembranes

, Volume 46, Issue 5, pp 403–420 | Cite as

Modelling mechanism of calcium oscillations in pancreatic acinar cells

  • Neeraj ManhasEmail author
  • K. R. Pardasani
Article

Abstract

We present a simple model for calcium oscillations in the pancreatic acinar cells. This model is based on the calcium release from two receptors, inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR) through the process of calcium induced calcium release (CICR). In pancreatic acinar cells, when the Ca2+ concentration increases, the mitochondria uptake it very fast to restrict Ca2+ response in the cell. Afterwards, a much slower release of Ca2+ from the mitochondria serves as a calcium supply in the cytosol which causes calcium oscillations. In this paper we discuss a possible mechanism for calcium oscillations based on the interplay among the three calcium stores in the cell: the endoplasmic reticulum (ER), mitochondria and cytosol. Our model predicts that calcium shuttling between ER and mitochondria is a pacemaker role in the generation of Ca2+oscillations. We also consider the calcium dependent production and degradation of (1,4,5) inositol-trisphosphate (IP3), which is a key source of intracellular calcium oscillations in pancreatic acinar cells. In this study we are able to predict the different patterns of calcium oscillations in the cell from sinusoidal to raised-baseline, high frequency and low-frequency baseline spiking.

Keywords

Pancreatic acinar cell Calcium oscillations CICR Raised-baseline MMOs 

Notes

Acknowledgments

The first author is highly thankful to Prof. James Sneyd for inviting him in the University of Auckland and giving him a chance to work under his guidance. The first author would like to thank Dr. Ganesh Dixit former faculty in the University of Auckland for providing him moral support during his stay in Auckland, New Zealand. Authors would like to thank Laurence Palk, and Kate Patterson at the University of Auckland, Ivo Siekmann (Now in the University of Melbourne) for the helpful discussion related to nonlinear dynamics.

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Authors and Affiliations

  1. 1.Department of Applied MathematicsMaulana Azad National Institute of TechnologyBhopalIndia

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