Journal of Bioenergetics and Biomembranes

, Volume 41, Issue 6, pp 465–467

Mitochondrial matters in Parkinson disease: introduction

Article

Abstract

Individuals with Parkinson disease (PD) are encountered frequently and have progressively severe neurologic changes. The central nervous system changes involve dopaminergic neurons in the basal ganglia and substantia nigra. Although usually sporadic, rare forms of PD are familial and the responsible genes have been identified. These genes affect mitochondrial function and can be studied in animals. Brains of affected animals reveal consequences of reactive oxygen species (ROS)—quinones, dopamine oxidation products, tyrosine nitration, lipid peroxidation and amino-aldehyde adducts. The three genes are important for maintaining physical and functional mitochondrial integrity. The cumulative effects of mitochondrial dysfunction, particularly those mediated by ROS, ultimately lead to at least some of the clinical and pathologic changes of PD.

Keywords

Mitochondrion Oxidation Neurodegeneration Mutation Parkinson 

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References

  1. Dagda RK, Chu CT (2009) J Bioenerg Biomemb 41:473–479Google Scholar
  2. Hastings TG (2009) J Bioenerg Biomemb 41:469–472Google Scholar
  3. Hatano Y, Sato Y, Elibol B, Yoshino H, Yamamura Y, Bonifiati V, Shinotoh H, Asahina M, Kobayashi S, Ng AR, Rosales RL, Hassin-Baer S et al (2004) Neurol 63:1482–1485Google Scholar
  4. Jendrach M, Gispert S, Ricciardi F, Klinkenberg M, Schemm R, Augurger G (2009) J Bioenerg Biomemb 41:481–486CrossRefGoogle Scholar
  5. Marella M, Seo BB, Yagi T, Matsuno-Yagi A (2009) J Bioenerg Biomemb 41:493–497CrossRefGoogle Scholar
  6. Navarro A, Boveris A (2009) J Bioenerg Biomemb 41:517–521CrossRefGoogle Scholar
  7. Papa S, Sardanelli AM, Capitanio N, Piccoli C (2009) J Bioenerg Biomemb 41:509–516CrossRefGoogle Scholar
  8. Powers WJ (2009) J Bioenerg Biomemb 41:505–508CrossRefGoogle Scholar
  9. Smith DJ (2009) J Bioenerg Biomemb 41:487–491CrossRefGoogle Scholar
  10. Takahashi H, Ohama E, Suzuki S, Horikawa Y, Ishikawa A, Morita T, Tsuji S, Ikuta F (1994) Neurol 44:437–441Google Scholar
  11. van Duijn CM, Dekker MCJ, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJLM, Testers L, Breedveld GJ, Horstink M, Sandkuijl LA, van Swieten JC, Oostra BA, Heutink P (2001) Am J Hum Genet 69:629–634CrossRefGoogle Scholar
  12. Whitworth AJ, Pallanck LJ (2009) J Bioenerg Biomemb 41:499–503CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Medicine and Biological ChemistryJohns Hopkins UniversityBaltimoreUSA

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