Journal of Bioenergetics and Biomembranes

, Volume 40, Issue 5, pp 407–410

A perspective on Peter Mitchell and the chemiosmotic theory



In 1991 Peter Mitchell wrote a last article that summarised his views on the origin, development and current status of his chemiosmotic ideas. I here review some of his views of that time on structures and mechanisms of several key bioenergetic components in relation to the subsequent advances that have been made.


Chemiosmotic theory Peter Mitchell Mitochondria Energy coupling Electron transfer 


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  1. Covian R, Trumpower BL (2008) Biochim Biophys Acta Bioenerg 1777:1044–1052CrossRefGoogle Scholar
  2. Crofts AR, Holland JT, Victoria D, Kolling DRJ, Dikanov SA, Gilbreth R, Lhee S, Kuras R, Kuras MG (2008) Biochim Biophys Acta Bioenerg 1777:1001–1009CrossRefGoogle Scholar
  3. Guan L, Kaback HR (2008) Annu Rev Biophys Biomol Struct 35:67–91CrossRefGoogle Scholar
  4. Mitchell P (1957) Nature 180:134–136CrossRefGoogle Scholar
  5. Mitchell P (1961) Nature 191:144–148CrossRefGoogle Scholar
  6. Mitchell P (1966) Coupling of phosphorylation to electron and proton transfer by a chemi-osmotic type of mechanism phosphorylation. Glynn Research Ltd, BodminGoogle Scholar
  7. Mitchell P (1968) Chemiosmotic coupling and energy transduction. Glynn Research Ltd, BodminGoogle Scholar
  8. Mitchell P (1976) J Theor Biol 62:327–367CrossRefGoogle Scholar
  9. Mitchell P (1979) Science 206:1148–1159CrossRefGoogle Scholar
  10. Mitchell P (1987) FEBS Lett 222:235–245CrossRefGoogle Scholar
  11. Mitchell P (1991) Biosci Rep 11:297–346CrossRefGoogle Scholar
  12. Mitchell R, Mitchell P, Rich PR (1992) Biochim Biophys Acta 1101:188–191Google Scholar
  13. Osyczka A, Moser CC, Daldal F, Dutton PL (2004) Nature 427:607–612CrossRefGoogle Scholar
  14. Rich PR (1995) Aust J Plant Physiol 22:479–486CrossRefGoogle Scholar
  15. Sazanov LA, Hinchliffe P (2006) Science 311:1430–1436CrossRefGoogle Scholar
  16. Walker JE (1998) Angew Chem Int Ed 37:2309–2319CrossRefGoogle Scholar
  17. Wikström M (1977) Nature 266:271–273CrossRefGoogle Scholar
  18. Wikström M (1989) Nature 338:776–778CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Glynn Laboratory of Bioenergetics, Institute of Structural and Molecular BiologyUniversity College LondonLondonUK

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