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Journal of Bioenergetics and Biomembranes

, Volume 39, Issue 1, pp 43–50 | Cite as

Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer

  • Kevin J. CullenEmail author
  • Zejia Yang
  • Lisa Schumaker
  • Zhongmin Guo
Mini Review

Abstract

Cisplatin is among the most important chemotherapeutic agents ever developed. It is a critical component of therapeutic regimens in a broad range of malignancies. However, more than a generation after its clinical introduction, the exact mechanism of cisplatin action on tumor cells is not fully defined. The preponderance of research over the last three decades has focused on cisplatin interactions with nuclear DNA which are felt to lead to apoptotic cell death in sensitive cells.

However, recent data have shown that cisplatin may have important direct interactions with mitochondria which can induce apoptosis and may account for a significant portion of the clinical activity associated with this drug. These direct interactions between cisplatin and mitochondria may have critical implications for our understanding of this class of drugs and the development of new therapeutic agents.

Keywords

cisplatin mitochondria head and neck cancer DNA voltage dependent anion channel 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Kevin J. Cullen
    • 1
    Email author
  • Zejia Yang
    • 1
  • Lisa Schumaker
    • 1
  • Zhongmin Guo
    • 1
  1. 1.University of Maryland Marlene and Stewart Greenebaum Cancer CenterBaltimoreUSA

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