Journal of Bioenergetics and Biomembranes

, Volume 38, Issue 3–4, pp 151–161 | Cite as

Translational approaches using metastasis suppressor genes

  • Diane Palmieri
  • Christine E. Horak
  • Jong-Heun Lee
  • Douglas O. Halverson
  • Patricia S. Steeg
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Abstract

Cancer metastasis is a significant contributor to breast cancer patient morbidity and mortality. In order to develop new anti-metastatic therapies, we need to understand the biological and biochemical mechanisms of metastasis. Toward these efforts, we and others have studied metastasis suppressor genes, which halt metastasis in vivo without affecting primary tumor growth. The first metastasis suppressor gene identified was nm23, also known as NDP kinase. Nm23 represents the most widely validated metastasis suppressor gene, based on transfection and knock-out mouse strategies. The biochemical mechanism of metastasis suppression via Nm23 is unknown and likely complex. Two potential mechanisms include binding proteins and a histidine kinase activity. Elevation of Nm23 expression in micrometastatic tumor cells may constitute a translational strategy for the limitation of metastatic colonization in high risk cancer patients. To date, medroxyprogesterone acetate (MPA) has been identified as a candidate compound for clinical testing.

Keywords

Nm23 RhoGDI2 Metastasis Metastasis suppressor Breast Cancer Histidine protein kinase 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Diane Palmieri
    • 1
  • Christine E. Horak
    • 1
  • Jong-Heun Lee
    • 1
  • Douglas O. Halverson
    • 1
  • Patricia S. Steeg
    • 1
  1. 1.Women’s Cancers Section, Laboratory of Molecular PharmacologyCenter for Cancer Research, National Cancer InstituteBethesdaUSA

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