Journal of Bioenergetics and Biomembranes

, Volume 37, Issue 6, pp 509–515 | Cite as

The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms

  • Christian Schölz
  • Robert Tampé


The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

Key Words

ABC transporter antigen presentation herpes virus immune evasion membrane proteins transport ATPases transporter associated with antigen processing virus persistence 



ATP-binding cassette


major histocompatibility complex


nucleotide-binding domain


transporter associated with antigen processing


transmembrane domain


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© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Institute of Biochemistry, BiocenterJohann Wolfgang Goethe-University FrankfurtFrankfurt a.M.Germany

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