The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms
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- Schölz, C. & Tampé, R. J Bioenerg Biomembr (2005) 37: 509. doi:10.1007/s10863-005-9500-1
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The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.
Key WordsABC transporter antigen presentation herpes virus immune evasion membrane proteins transport ATPases transporter associated with antigen processing virus persistence
major histocompatibility complex
transporter associated with antigen processing