Journal of Bioenergetics and Biomembranes

, Volume 37, Issue 3, pp 155–164

The Role of the Mitochondrial Apoptosis Induced Channel MAC in Cytochrome c Release

  • Sonia Martinez-Caballero
  • Laurent M. Dejean
  • Elizabeth A. Jonas
  • Kathleen W. Kinnally
Article

DOI: 10.1007/s10863-005-6570-z

Cite this article as:
Martinez-Caballero, S., Dejean, L.M., Jonas, E.A. et al. J Bioenerg Biomembr (2005) 37: 155. doi:10.1007/s10863-005-6570-z

Abstract

Permeabilization of the mitochondrial outer membrane is a crucial event during apoptosis. It allows the release of proapoptotic factors, like cytochrome c, from the intermembrane space, and represents the commitment step in apoptosis. The mitochondrial apoptosis-induced channel, MAC, is a high-conductance channel that forms during early apoptosis and is the putative cytochrome c release channel. Unlike activation of the permeability transition pore, MAC formation occurs without loss of outer membrane integrity and depolarization. The single channel behavior and pharmacology of reconstituted MAC has been characterized with patch-clamp techniques. Furthermore, MAC’s activity is compared to that detected in mitochondria inside the cells at the time cytochrome c is released. Finally, the regulation of MAC by the Bcl-2 family proteins and insights concerning its molecular composition are also discussed.

Keywords

Mitochondrial apoptosis-induced channel MAC patch clamp cytochrome c Bax 

Abbreviations:

MAC

Mitochondrial apoptosis-induced channel

PTP

Permeability transition pore

TOM

Translocase of the outer membrane

VDAC

Voltage-dependent anion-selective channel

IL-3

Interleukin 3

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Sonia Martinez-Caballero
    • 1
  • Laurent M. Dejean
    • 1
  • Elizabeth A. Jonas
    • 2
  • Kathleen W. Kinnally
    • 1
    • 3
  1. 1.Department of Basic SciencesNew York University, College of DentistryNew York
  2. 2.Department of Internal MedicineYale University School of MedicineNew Haven
  3. 3.Department of Basic SciencesNew York University, College of DentistryNew York

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