Eveningness and Seasonality are Associated with the Bipolar Disorder Vulnerability Trait

  • Ben BullockEmail author
  • Janelle Corlass-Brown
  • Greg Murray


Trait theories of vulnerability to bipolar disorder (BD) are increasingly common in the literature, yet poorly understood. The aim of the current study was to complement existing knowledge of trait theories by investigating two biological rhythm features often associated with BD – eveningness and seasonality – in a sample assessed as vulnerable to the disorder. Two hundred and thirteen participants completed an online survey consisting of the General Behavior Inventory, Seasonal Pattern Assessment Questionnaire, and Morningness-Eveningness Questionnaire. Hierarchical regressions controlling for sex and age showed that greater levels of seasonality and a tendency towards an eveningness chronotype were weak, but significant predictors of the BD vulnerability trait. When the traits of vulnerability to depression and mania were investigated separately, seasonality and eveningness were significant predictors of the former, but only seasonality was a significant predictor of the latter. The Autumn/Winter pattern of seasonality was a weak predictor of trait vulnerability to mania but not depression. The current findings advance understanding of the BD vulnerability trait, and may have consequences for the behavioural management of those who are considered to be ‘at risk’ of the disorder.


Bipolar disorder Morningness Eveningness Seasonality Vulnerability 


Conflict of Interest

The authors declare that they have no conflicts of interest with respect to the authorship, conduct, or publication of this article.

Experiment Participants

Ethical approval for the study was gained from the local university Human Research Ethics Committee and study procedures comply with the Australian Code for Responsible Conduct of Research. Participants’ informed consent was implied from submission of the anonymous questionnaire.


  1. Adan, A., & Natale, V. (2002). Gender differences in morningness-eveningness preference. Chronobiology International, 19(4), 709–720. doi: 10.1081/cbi-120005390.PubMedCrossRefGoogle Scholar
  2. Ahn, Y. M., Chang, J., Joo, Y. H., Kim, S. C., Lee, K. Y., & Kim, Y. S. (2008). Chronotype distribution in bipolar I disorder and schizophrenia in a Korean sample. Bipolar Disorders, 10(2), 271–275.PubMedCrossRefGoogle Scholar
  3. Alloy, L. B., Abramson, L. Y., Walshaw, P. D., Gerstein, R. K., Keyser, J. D., Whitehouse, W. G., et al. (2009). Behavioral Approach System (BAS)-relevant cognitive styles and bipolar spectrum disorders: concurrent and prospective associations. Journal of Abnormal Psychology, 118(3), 459–471.PubMedCentralPubMedCrossRefGoogle Scholar
  4. Ankers, D., & Jones, S. H. (2009). Objective assessment of circadian activity and sleep patterns in individuals at behavioral risk of hypomania. Journal of Clinical Psychology, 65(10), 1071–1086. doi: 10.1002/jclp.20608.PubMedCrossRefGoogle Scholar
  5. APA. (2013). DSM-5. Washington, DC: Author.Google Scholar
  6. Ashman, S. B., Monk, T. H., Kupfer, D. J., Clark, C. H., Myers, F. S., Frank, E., et al. (1999). Relationship between social rhythms and mood in patients with rapid cycling bipolar disorder. Psychiatry Research, 86, 1–8.PubMedCrossRefGoogle Scholar
  7. Bardram, J. E., Frost, M., Szántó, K., & Marcu, G. The MONARCA self-assessment system - A persuasive personal monitoring system for bipolar patients. In 2nd ACM SIGHIT International Health Informatics Symposium, Miami, FL, 2012 (pp. 21–30, 2nd ACM SIGHIT International Health Informatics Symposium, IHI’12). doi: 10.1145/2110363.2110370.
  8. Boland, E. M., Bender, R. E., Alloy, L. B., Conner, B. T., LaBelle, D. R., & Abramson, L. Y. (2012). Life events and social rhythms in bipolar spectrum disorders: an examination of social rhythm sensitivity. Journal of Affective Disorders, 139(3), 264–272. doi: 10.1016/j.jad.2012.01.038.PubMedCentralPubMedCrossRefGoogle Scholar
  9. Bullock, B., & Murray, G. (2013). Reduced amplitude of the 24-hr activity rhythm: a biomarker of vulnerability to bipolar disorder? [Advance online publication]. Clinical Psychological Science. doi: 10.1177/2167702613490158.Google Scholar
  10. Bullock, B., Judd, F., & Murray, G. (2011). Social rhythms and vulnerability to bipolar disorder. [Brief Report]. Journal of Affective Disorders, 135(1–3), 384–388.PubMedCrossRefGoogle Scholar
  11. Camp, N. J., Lowry, M. R., Lynn Richards, R., Plenk, A. M., Carter, C., Hensel, C. H., et al. (2005). Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. American Journal of Medical Genetics - Neuropsychiatric Genetics, 135 B(1), 85–93.CrossRefGoogle Scholar
  12. Carrier, J., Monk, T. H., Buysse, D. J., & Kupfer, D. J. (1997). Sleep and morningness-eveningness in the “middle” years of life (20–59 y). Journal of Sleep Research, 6, 230–237.PubMedCrossRefGoogle Scholar
  13. Carver, C. S., & Johnson, S. L. (2009). Tendencies toward mania and tendencies toward depression have distinct motivational, affective, and cognitive correlates. Cognitive Therapy and Research, 33(6), 552–569.PubMedCentralPubMedCrossRefGoogle Scholar
  14. Ciarleglio, C. M., Resuehr, H. E. S., & McMahon, D. G. (2011). Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience, 197, 8–16. doi: 10.1016/j.neuroscience.2011.09.036.PubMedCrossRefGoogle Scholar
  15. Daimon, K., Yamada, N., Tsujimoto, T., & Takahashi, S. (1992). Circadian rhythm abnormalities of deep body temperature in depressive disorders. Journal of Affective Disorders, 26, 191–198.PubMedCrossRefGoogle Scholar
  16. Dallaspezia, S., & Benedetti, F. (2011). Chronobiological therapy for mood disorders. Expert Review of Neurotherapeutics, 11(7), 961–970.PubMedCrossRefGoogle Scholar
  17. de Medeiros Schneider, M. L., Vasconcellos, D. C., Dantas, G., Levandovski, R., Caumo, W., Allebrandt, K. V., et al. (2011). Morningness-eveningness, use of stimulants, and minor psychiatric disorders among undergraduate students. International Journal of Psychology, 46(1), 18–23. doi: 10.1080/00207594.2010.513414.CrossRefGoogle Scholar
  18. Depue, R. A., & Iacono, W. G. (1989). Neurobehavioural aspects of affective disorders. Annual Review of Psychology, 40, 457–492.PubMedCrossRefGoogle Scholar
  19. Depue, R. A., & Klein, D. N. (1988). Identification of unipolar and bipolar affective conditions in nonclinical and clinical populations by the General Behavior Inventory. In D. L. Dunner, E. S. Gershon, & J. E. Barrett (Eds.), Relatives at risk for mental disorder (pp. 179–204). New York: Raven Press, Ltd.Google Scholar
  20. Depue, R. A., Krauss, S., Spoont, M. R., & Arbisi, P. (1989). General behaviour inventory identification of unipolar and bipolar affective conditions in a nonclinical university population. Journal of Abnormal Psychology, 98(2), 117–126.PubMedCrossRefGoogle Scholar
  21. Eckblad, M., & Chapman, L. J. (1986). Development and validation of a scale for hypomanic personality. Journal of Abnormal Psychology, 95(3), 214–222.PubMedCrossRefGoogle Scholar
  22. Evans, L., Akiskal, H. S., Keck, P. E., Jr., McElroy, S. L., Sadovnick, A. D., Remick, R. A., et al. (2005). Familiality of temperament in bipolar disorder: support for a genetic spectrum. Journal of Affective Disorders, 85(1–2), 153–168.PubMedCrossRefGoogle Scholar
  23. Findling, R. L., Youngstrom, E. A., Danielson, C. K., DelPorto-Bedoya, D., Papish-David, R., Townsend, L., et al. (2002). Clinical decision-making using the General Behavior Inventory in juvenile bipolarity. Bipolar Disorders, 4(1), 34–42.PubMedCrossRefGoogle Scholar
  24. Frantom, L. V., Allen, D. N., & Cross, C. L. (2008). Neurocognitive endophenotypes for bipolar disorder. Bipolar Disorders, 10(3), 387–399. doi: 10.1111/j.1399-5618.2007.00529.x.PubMedCrossRefGoogle Scholar
  25. Gershon, E. S., Hamovit, J., Guroff, J. J., Dibble, E., Leckman, J. F., Sceery, W., et al. (1982). A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry, 39(10), 1157–1167.PubMedCrossRefGoogle Scholar
  26. Goikolea, J. M., Colom, F., Martínez-Arán, A., Sánchez-Moreno, J., Giordano, A., Bulbena, A., et al. (2007). Clinical and prognostic implications of seasonal pattern in bipolar disorder: a 10-year follow-up of 302 patients. Psychological Medicine, 37(11), 1595–1599. doi: 10.1017/s0033291707000864.PubMedCrossRefGoogle Scholar
  27. Hakkarainen, R., Johansson, C., Kieseppa, T., Partonen, T., Koskenvuo, M., Kaprio, J., et al. (2003). Seasonal changes, sleep length and circadian preference among twins with bipolar disorder. BMC Psychiatry, 3, 6.PubMedCentralPubMedCrossRefGoogle Scholar
  28. Harvey, A. G., Schmidt, D. A., Scarna, A., Semler, C. N., & Goodwin, G. M. (2005). Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems. American Journal of Psychiatry, 162(1), 50–57.PubMedCrossRefGoogle Scholar
  29. Haslam, N., Holland, E., & Kuppens, P. (2012). Categories versus dimensions in personality and psychopathology: a quantitative review of taxometric research. Psychological Medicine, 42(5), 903–920. doi: 10.1017/s0033291711001966.PubMedCrossRefGoogle Scholar
  30. Horne, J. A., & Ostberg, O. (1976). A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. International Journal of Chronobiology, 4, 97–110.PubMedGoogle Scholar
  31. Johnson, S. L., Edge, M. D., Holmes, M. K., & Carver, C. S. (2012). The behavioral activation system and mania. Annual Review of Clinical Psychology, 8, 243–267.PubMedCentralPubMedCrossRefGoogle Scholar
  32. Judd, L. L., Akiskal, H. S., Schettler, P. J., Coryell, W., Endicott, J., Maser, J. D., et al. (2003). A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Archives of General Psychiatry, 60(3), 261–269. doi: 10.1001/archpsyc.60.3.261.PubMedCrossRefGoogle Scholar
  33. Kapczinski, F., Vieta, E., Andreazza, A. C., Frey, B. N., Gomes, F. A., Tramontina, J., et al. (2008). Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neuroscience and Biobehavioral Reviews, 32(4), 675–692.PubMedCrossRefGoogle Scholar
  34. Kelly, R. E., Mansell, W., Sadhnani, V., & Wood, A. M. (2012). Positive and negative appraisals of the consequences of activated states uniquely relate to symptoms of hypomania and depression. Cognition and Emotion, 26(5), 899–906.PubMedCrossRefGoogle Scholar
  35. Kelsoe, J. R. (2003). Arguments for the genetic basis of the bipolar spectrum. Journal of Affective Disorders, 73(1–2), 183–197.PubMedCrossRefGoogle Scholar
  36. Koukopoulos, A., Sani, G., Koukopoulos, A. E., Albert, M. J., Girardi, P., & Tatarelli, R. (2006). Endogenous and exogenous cyclicity and temperament in bipolar disorder: review, new data and hypotheses. Journal of Affective Disorders, 96(3), 165–175. doi: 10.1016/j.jad.2006.08.031.PubMedCrossRefGoogle Scholar
  37. Lamont, E. W., Legault-Coutu, D., Cermakian, N., & Boivin, D. B. (2007). The role of circadian clock genes in mental disorders. Dialogues in Clinical Neuroscience, 9(3), 333–342.PubMedGoogle Scholar
  38. Lee, H. C., Tsai, S. Y., & Lin, H. C. (2007). Seasonal variations in bipolar disorder admissions and the association with climate: a population-based study. Journal of Affective Disorders, 97(1–3), 61–69.PubMedCrossRefGoogle Scholar
  39. Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., et al. (2005). Circadian phase variation in bipolar I disorder. Chronobiology International, 22(3), 571–584.PubMedCrossRefGoogle Scholar
  40. McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., & Cardno, A. (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry, 60, 497–502.PubMedCrossRefGoogle Scholar
  41. Mersch, P. P. A., Vastenburg, N. C., Meesters, Y., Bouhuys, A. L., Beersma, D. G. M., Van Den Hoofdakker, R. H., et al. (2004). The reliability and validity of the Seasonal Pattern Assessment Questionnaire: a comparison between patient groups. Journal of Affective Disorders, 80(2–3), 209–219. doi: 10.1016/s0165-0327(03)00114-9.PubMedCrossRefGoogle Scholar
  42. Murray, G. (2003). The Seasonal Pattern Assessment Questionnaire as a measure of mood seasonality: a prospective validation study. Psychiatry Research, 120(1), 53–59.PubMedCrossRefGoogle Scholar
  43. Murray, G., & Harvey, A. (2010). Circadian rhythms and sleep in bipolar disorder. Bipolar Disorders, 12(5), 459–472. doi: 10.1111/j.1399-5618.2010.00843.x.PubMedCrossRefGoogle Scholar
  44. Murray, G., Goldstone, E., & Cunningham, E. (2007). Personality and the predisposition(s) to bipolar disorder: heuristic benefits of a two-dimensional model. Bipolar Disorders, 9(5), 453–461. doi: 10.1111/j.1399-5618.2007.00456.x.PubMedCrossRefGoogle Scholar
  45. Murray, G., Lam, R. W., Beaulieu, S., Sharma, V., Cervantes, P., Parikh, S. V., et al. (2011). Do symptoms of bipolar disorder exhibit seasonal variation? A multisite prospective investigation. Bipolar Disorders, 13(7–8), 687–695. doi: 10.1111/j.1399-5618.2011.00959.x.PubMedCrossRefGoogle Scholar
  46. Natale, V., & Cicogna, P. (2002). Morningness-eveningness: is it really a continuum? Personality & Individual Differences, 32(5), 809–816.CrossRefGoogle Scholar
  47. Nathan, P. J., Burrows, G. D., & Norman, T. R. (1999). Melatonin sensitivity to dim white light in affective disorders. Neuropsychopharmacology, 21(3), 408–413. doi: 10.1016/s0893-133x(99)00018-4.PubMedCrossRefGoogle Scholar
  48. Nurnberger, J. I., Adkins, S., Lahiri, D. K., Mayeda, A., Hu, K., Lewy, A. J., et al. (2000). Melatonin suppression by light in euthymic bipolar and unipolar patients. Archives of General Psychiatry, 57(6), 572–579.PubMedCrossRefGoogle Scholar
  49. Ottoni, G. L., Lorenzi, T. M., & Lara, D. R. (2011). Association of temperament with subjective sleep patterns. Journal of Affective Disorders, 128(1–2), 120–127. doi: 10.1016/j.jad.2010.06.014.PubMedCrossRefGoogle Scholar
  50. Oyane, N. M. F., Bjelland, I., Pallesen, S., Holsten, F., & Bjorvatn, B. (2008). Seasonality is associated with anxiety and depression: the Hordaland health study. Journal of Affective Disorders, 105(1–3), 147–155. doi: 10.1016/j.jad.2007.05.002.PubMedCrossRefGoogle Scholar
  51. Parslow, R. A., Jorm, A. F., Butterworth, P., Jacomb, P. A., & Rodgers, B. (2004). An examination of seasonality experienced by Australians living in a continental temperate climate zone. Journal of Affective Disorders, 80(2–3), 181–190. doi: 10.1016/s0165-0327(03)00113-7.PubMedCrossRefGoogle Scholar
  52. Prociow, P. A., & Crowe, J. A. (2010). Towards personalised ambient monitoring of mental health via mobile technologies. Technology and Health Care, 18(4–5), 275–284. doi: 10.3233/thc-2010-0590.PubMedGoogle Scholar
  53. Reichart, C. G., Van Der Ende, J., Wals, M., Hillegers, M. H. J., Ormel, J., Nolen, W. A., et al. (2004). The use of the GBI in a population of adolescent offspring of parents with a bipolar disorder. Journal of Affective Disorders, 80(2–3), 263–267.PubMedCrossRefGoogle Scholar
  54. Roberts, R. D., & Kyllonen, P. C. (1999). Morningness-eveningness and intelligence: early to bed, early to rise will likely make you anything but wise! Personality and Individual Differences, 27(6), 1123–1133. doi: 10.1016/s0191-8869(99)00054-9.PubMedCrossRefGoogle Scholar
  55. Rosenthal, N. E., Bradt, G. H., & Wehr, T. A. (1984). Seasonal Pattern Assessment Questionnaire. Bethesda: National Institute of Mental Health.Google Scholar
  56. Savitz, J., van der Merwe, L., & Ramesar, R. (2008). Hypomanic, cyclothymic and hostile personality traits in bipolar spectrum illness: a family-based study. Journal of Psychiatric Research, 42(11), 920–929.PubMedCrossRefGoogle Scholar
  57. Schaffer, A., Levitt, A. J., & Boyle, M. (2003). Influence of season and latitude in a community sample of subjects with bipolar disorder. Canadian Journal of Psychiatry, 48(4), 277–280.Google Scholar
  58. Schweitzer, I., Maguire, K., & Ng, C. H. (2005). Should bipolar disorder be viewed as manic disorder? Implications for bipolar disorder. Bipolar Disorders, 7, 418–423.PubMedCrossRefGoogle Scholar
  59. Shand, A. J., Scott, N. W., Anderson, S. M., & Eagles, J. M. (2011). The seasonality of bipolar affective disorder: comparison with a primary care sample using the Seasonal Pattern Assessment Questionnaire. Journal of Affective Disorders, 132(1–2), 289–292. doi: 10.1016/j.jad.2011.02.015.PubMedCrossRefGoogle Scholar
  60. Shen, G. H. C., Sylvia, L. G., Alloy, L. B., Barrett, F., Kohner, M., Iacoviello, B., et al. (2008). Lifestyle regularity and cyclothymic symptomatology. Journal of Clinical Psychology, 64(4), 482–500.PubMedCrossRefGoogle Scholar
  61. Simonsen, H., Shand, A. J., Scott, N. W., & Eagles, J. M. (2011). Seasonal symptoms in bipolar and primary care patients. Journal of Affective Disorders, 132(1–2), 200–208. doi: 10.1016/j.jad.2011.02.018.PubMedCrossRefGoogle Scholar
  62. Smith, C. S., Reilly, C., & Midkiff, K. (1989). Evaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. Journal of Applied Psychology, 74(5), 728–738.PubMedCrossRefGoogle Scholar
  63. Souetre, E., Salvati, E., Wehr, T. A., Sack, D. A., Krebs, B., & Darcourt, G. (1988). Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects. American Journal of Psychiatry, 145(9), 1133–1137.PubMedGoogle Scholar
  64. Suhail, K., & Cochrane, R. (1998). Seasonal variations in hospital admissions for affective disorders by gender and ethnicity. Social Psychiatry and Psychiatric Epidemiology, 33(5), 211–217.PubMedCrossRefGoogle Scholar
  65. Tonetti, L., Barbato, G., Fabbri, M., Adan, A., & Natale, V. (2007). Mood seasonality: a cross-sectional study of subjects aged between 10 and 25 years. Journal of Affective Disorders, 97(1–3), 155–160.PubMedCrossRefGoogle Scholar
  66. Wood, J., Birmaher, B., Axelson, D., Ehmann, M., Kalas, C., Monk, K., et al. (2009). Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals. Psychiatry Research, 166(2–3), 201–209. doi: 10.1016/j.psychres.2008.03.003.PubMedCentralPubMedCrossRefGoogle Scholar
  67. Young, M. A., Blodgett, C., & Reardon, A. (2003). Measuring seasonality: psychometric properties of the Seasonal Pattern Assessment Questionnaire and the Inventory for Seasonal Variation. Psychiatry Research, 117(1), 75–83.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ben Bullock
    • 1
    Email author
  • Janelle Corlass-Brown
    • 2
  • Greg Murray
    • 1
  1. 1.Department of Psychological Sciences and StatisticsSwinburne University of TechnologyHawthornAustralia
  2. 2.School of Psychology (St. Patrick’s)Australian Catholic UniversityFitzroy MDCAustralia

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