Journal of Biomolecular NMR

, Volume 63, Issue 1, pp 9–19 | Cite as

Fast multi-dimensional NMR acquisition and processing using the sparse FFT

  • Haitham Hassanieh
  • Maxim Mayzel
  • Lixin Shi
  • Dina Katabi
  • Vladislav Yu OrekhovEmail author


Increasing the dimensionality of NMR experiments strongly enhances the spectral resolution and provides invaluable direct information about atomic interactions. However, the price tag is high: long measurement times and heavy requirements on the computation power and data storage. We introduce sparse fast Fourier transform as a new method of NMR signal collection and processing, which is capable of reconstructing high quality spectra of large size and dimensionality with short measurement times, faster computations than the fast Fourier transform, and minimal storage for processing and handling of sparse spectra. The new algorithm is described and demonstrated for a 4D BEST-HNCOCA spectrum.


Compressed sensing Reduced dimensionality Non uniform sampling Fast NMR 



The work was supported by the Swedish Research Council (Research Grant 2011-5994); Swedish National Infrastructure for Computing (Grant SNIC 001/12-271). The Swedish NMR Centre is acknowledged for spectrometer time.

Supplementary material

10858_2015_9952_MOESM1_ESM.docx (155 kb)
Supplementary material 1 (DOCX 155 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Haitham Hassanieh
    • 1
  • Maxim Mayzel
    • 2
  • Lixin Shi
    • 1
  • Dina Katabi
    • 1
  • Vladislav Yu Orekhov
    • 2
    Email author
  1. 1.Massachusetts Institute of TechnologyCambridgeUSA
  2. 2.Swedish NMR Centre at University of GothenburgGothenburgSweden

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