Practical considerations over spectral quality in solid state NMR spectroscopy of soluble proteins
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- Fragai, M., Luchinat, C., Parigi, G. et al. J Biomol NMR (2013) 57: 155. doi:10.1007/s10858-013-9776-0
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Great theoretical and methodological advances are pushing the limits of resolution and sensitivity in solid state NMR (SSNMR). However, sample preparation remains a critical issue for the success of an experiment. The factors affecting spectral quality in SSNMR samples are discussed, examining cases encountered in the literature and presenting new experimental data. A discussion on resolution and sensitivity in sedimented solutes is framed in this context.