Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t
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Plants have evolved two major layers of defense mechanisms against invasion by diverse pathogens. When host membranes are exposed to pathogens, plants use extracellular surface receptors to identify pathogen-associated molecular patterns (PAMPs) and initiate so-called PAMP-triggered immunity (PTI) (Chisholm et al. 2006). Once pathogens gain hold in plants by suppressing this primary defense, plants express cytoplasmic resistance proteins that recognize pathogen-derived effector proteins and mount a more specialized defense mechanism referred to as effector-triggered immunity (ETI, Chisholm et al. 2006). To enable parasitism, pathogens usually use an arsenal of effector proteins that are delivered into plant cells to exert their primary function of interfering with the host immunity (Abramovitch et al. 2006; Feng et al. 2012; Wilton et al. 2010). However, effector proteins in some cases act as traitors by inducing effector-triggered immunity; these proteins are often...
KeywordsRice Blast Distance Restraint Chemical Shift Assignment Stable Fragment Side Chain Resonance Assignment
This work was supported by grants from the National Program on Key Basic Research of China (2009CB918600, to J. Z. and M. L.), the National Grand Project for Medicine Innovation (2011ZX09506-001) and the Natural Science Foundation in China (30971878, to B. Z.). We are grateful to Prof. Chunyang Cao and Yan Zhang for valuable suggestions in NMR structure determination. We also thank Dr. Wenyu Wen for her help on H/D exchange experiments.
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