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Effect of biomaterials hydrophobicity and roughness on biofilm development

  • Iker De-la-Pinta
  • Mónica Cobos
  • Julen Ibarretxe
  • Elizabeth Montoya
  • Elena Eraso
  • Teresa Guraya
  • Guillermo QuindósEmail author
Biomaterials Synthesis and Characterization Original Research
Part of the following topical collections:
  1. Biomaterials Synthesis and Characterization

Abstract

Most hospitalized patients are carriers of biomedical devices. Infections associated with these devices cause great morbidity and mortality, especially in patients in intensive care units. Numerous strategies have been designed to prevent biofilm development on biodevices. However, biofilm formation is a complex process not fully clarified. In the current study, roughness and hydrophobicity of different biomaterials was analyzed to assess their influences on the biofilm formation of four leading etiological causes of healthcare-associated infections, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis and Candida albicans, using a CDC biofilm reactor. Hydrophobic materials allowed the formation of more abundant and profuse biofilms. Roughness had effect on biofilm formation, but its influence was not significant when material hydrophobicity was considered.

Notes

Acknowledgements

We thank Dr Francisco José Álvarez and Dr Hector Lafuente from BioCruces Health Research Institute for their excellent technical assistance as well as Dr Ane Miren Zaldua from Leartiker Polymer R&D for the provision of the polyurethane disks. Our gratitude is extended to the Analytical and High-Resolution Microscopy Service of the Universidad del País Vasco/Euskal Herriko Unibertsitatea (Sgiker) for the SEM imaging. ID-l-P received a scholarship from the ZabaldUz program (Universidad del País Vasco/Euskal Herriko Unibertsitatea). This work was supported by the Consejería de Educación, Universidades e Investigación of the Gobierno Vasco-Eusko Jaularitza [GIC 15/78 IT-990-16] and the Universidad del País Vasco/Euskal Herriko Unibertsitatea [UFI 11/25].

Compliance with ethical standards

Conflict of interest

We have no specific conflicts of interest related to the current manuscript but declare the following: GQ has received research grants from Astellas Pharma, Pfizer, Merck Sharp & Dohme, and Scynexis. GQ has served on advisory/consultant boards for Merck, Sharp & Dohme, and Scynexis, and he has received speaker honoraria from Abbvie, Astellas Pharma, Merck Sharp & Dohme, Pfizer, and Scynexis. EE has received grant support from Astellas Pharma and Pfizer SLU. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed above.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Departamento de Inmunología, Microbiología y Parasitología, UFI 11/25, Facultad de Medicina y EnfermeríaUniversidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHUBilbaoSpain
  2. 2.Departamento de Ciencia y Tecnología de Polímeros, Facultad de QuímicaUniversidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHUSan SebastiánSpain
  3. 3.Departamento de Física aplicada I, Escuela de Ingeniería de BilbaoUniversidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHUBilbaoSpain
  4. 4.Leartiker Polymer R&D, LeartikerMarkina-XemeinSpain
  5. 5.Departamento de Ingeniería Minera y Metalúrgica y Ciencia de los Materiales, Escuela de Ingeniería de BilbaoUniversidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHUBilbaoSpain

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