Defragmentation of lysozyme derived Amyloid β fibril using Biocompatible Magnetic fluid

  • Nidhi P. Parikh
  • Kinnari H. ParekhEmail author
Biomaterials Synthesis and Characterization Original Research
Part of the following topical collections:
  1. Biomaterials Synthesis and Characterization


We present here a modulating effect on lysozyme derived Amyloid β fibrils by aqueous magnetic fluid. This non-conventional approach of treatment of lysozyme derived Amyloid β fibrils showed lysing of Amyloid fibrils to its secondary structures which can be seen using optical microscope and scanning electron microscopic image. The size of lysozyme derived amyloid fibrils before and after treatment was measured using dynamic light scattering technique. The mechanism of defragmentation of lysozyme derived Amyloid β fibrils by magnetic fluid is explained. This is a first report to identify the secondary structure of protein using Fourier Transform Infrared (FTIR) and Circular Dichroism (CD) spectra after lysing. The cyto-toxicity study of this magnetic fluid on neuronal (SH-SY5Y) and non-neuronal (NRK) cell lines shows non-toxicity up to a concentration of 250 μg/mL. The study indicates a novel and unique complementary approach to treat the amyloidogenic brain diseases.



Authors would like to thank DST, Govt. of India for providing financial support to NP under technology development project no. 161-G and CHARUSAT for providing experimental facilities.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Dr. K C Patel R & D CenterCharotar University of Science & TechnologyDist. AnandIndia

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