An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study
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Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 °C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover. In vitro, the composite hydrogel of BP-12 and gelatin had good biocompatibility with the fibroblast cells. In vivo, rapid cutaneous-tissue regeneration and tissue-structure formation within 7 days was observed in the wound-healing experiment performed in rats. This hydrogel is thus a promising easy-to-use wound dressing material.
KeywordsGelatin Wound Closure Bioactive Glass Composite Hydrogel Fibroblast L929 Cell
This work was supported by MOST (Project No. 2012CB933200, 2013DFG52300) and NSFC (Project No. 21474122, 51173193, 81202931).
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Conflict of interest
The authors declare that they have no competing interests.
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