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Injectable micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs

  • CuiXiang Fu
  • XiaoXiao Lin
  • Jun Wang
  • XiaoQun Zheng
  • XingYi Li
  • ZhengFeng Lin
  • GuangYong LinEmail author
Delivery Systems Original Research
Part of the following topical collections:
  1. Delivery Systems

Abstract

In this paper, an injectable micellar supramolecular hydrogel composed of α-cyclodextrin (α-CD) and monomethoxy poly(ethylene glycol)-b-poly(ε-caplactone) (MPEG5000-PCL5000) micelles was developed by a simple method for hydrophobic anticancer drug delivery. By mixing α-CD aqueous solution and MPEG5000-PCL5000 micelles, an injectable micellar supramolecular hydrogel could be formed under mild condition due to the inclusion complexation between α-CD and MPEG segment of MPEG5000-PCL5000 micelles. The resultant supramolecular hydrogel was thereafter characterized by X-ray diffraction (XRD) and Scanning electron microscopy (SEM). The effect of α-CD amount on the gelation time, mechanical strength and thixotropic property was studied by a rheometer. Payload of hydrophobic paclitaxel (PTX) to supramolecular hydrogel was achieved by encapsulation of PTX into MPEG5000-PCL5000 micelles prior mixing with α-CD aqueous solution. In vitro release study showed that the release behavior of PTX from hydrogel could be modulated by change the α-CD amount in hydrogel. Furthermore, such supramolecular hydrogel could enhance the biological activity of encapsulated PTX compared to free PTX, as indicated by in vitro cytotoxicity assay. All these results indicated that the developed micellar supramolecular hydrogel might be a promising injectable drug delivery system for anticancer therapy.

Graphical Abstract

Keywords

Gelation Time Hydrophobic Drug Hydrogel Sample Control Drug Delivery System Supramolecular Hydrogel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thanks to the synthesis of MPEG5000-PCL5000 block polymer by Li XY. The authors acknowledge the financial support from Zhejiang Medicines Health Science and Technology Program (2012KYB132).

Supplementary material

Supplementary material 1 (MOV 27293 kb)

10856_2016_5682_MOESM2_ESM.docx (1.9 mb)
Supplementary material 2 (DOCX 1963 kb)

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • CuiXiang Fu
    • 1
  • XiaoXiao Lin
    • 1
  • Jun Wang
    • 1
  • XiaoQun Zheng
    • 2
  • XingYi Li
    • 3
  • ZhengFeng Lin
    • 1
  • GuangYong Lin
    • 1
    Email author
  1. 1.Department of PharmacyThe Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China
  2. 2.Department of Laboratory MedicineThe Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China
  3. 3.Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye hospitalWenzhou Medical UniversityWenzhouPeople’s Republic of China

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