A bioresorbable polylactide implant used in bone cyst filling

  • Krzysztof FicekEmail author
  • Jolanta Filipek
  • Piotr Wojciechowski
  • Konrad Kopec
  • Stodolak-Zych Ewa
  • Stanislaw Blazewicz
Biomaterials Synthesis and Characterization Clinical Investigation
Part of the following topical collections:
  1. Biomaterials Synthesis and Characterization


The aims in treating patients diagnosed with critical-sized bone defects resulting from bone cysts are to replace the lost bone mass after its removal and to restore function. The standard treatment is autologous or allogeneic bone transplantation, notwithstanding the known consequences and risks due to possible bone infection, donor site morbidity, bleeding and nerve injury and possible undesirable immune reactions. Additionally, allogeneic grafts are inhomogeneous, with a mosaic of components with difficult-to-predict regenerative potential, because they consist of cancellous bone obtained from different bones from various cadavers. In the present study, a 22-year-old patient with a history of right humerus fracture due to bone cysts was diagnosed with recurrent cystic lesions based on X-ray results. The patient qualified for an experimental program, in which he was treated with the application of a bioresorbable polylactide hybrid sponge filled with autologous platelet-rich plasma. Computed tomography and magnetic resonance imaging performed 3, 6, and 36 months after surgery showed progressive ossification and bone formation inside the defect cavity in the humerus. Three years after treatment with the bone substitute, the patient is pain free, and the cystic lesions have not reoccurred.


Sponge Bone Defect Cystic Lesion Bone Cyst Bone Substitute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by the kind cooperation of Bioimplant, Ltd., Poland.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Gobin AS, Froude VE, Mathur AB. Structural and mechanical characteristics of silk fibroin and chitosan blend scaffolds for tissue regeneration. J Biomed Mater Res A. 2005;74:465–73. doi: 10.1002/jbm.a.30382.CrossRefGoogle Scholar
  2. 2.
    Ip WY, Gogolewski S. Clinical application of resorbable polymers in guided Bone regeneration. Macromol Symp. 2007;253:139–46.CrossRefGoogle Scholar
  3. 3.
    Sverzut CE, Faria PEP, Magdalena CM, Trivellato AE, Mello-Filho FV, Paccola CA, Gogolewski S, Salata LA. Reconstruction of mandibular segmental defects using the guided-bone regeneration technique with polylactide membranes and/or autogenous bone graft: a preliminary study on the influence of membrane permeability. J Oral Maxillofac Surg. 2008;66:647–56. doi: 10.1016/j.joms.2007.06.664.CrossRefGoogle Scholar
  4. 4.
    Leiggener CS, Curtis R, Müller AA. Influence of copolymer composition of polylactide implants on cranial bone regeneration. Biomaterials. 2006;27:202–7. doi: 10.1016/j.biomaterials.2005.05.068.CrossRefGoogle Scholar
  5. 5.
    Slomkowski S. Biodegradable polyesters for tissue engineering. Macromol Symp. 2007;253:47–58. doi: 10.1002/masy.200750706.CrossRefGoogle Scholar
  6. 6.
    Ranly D, Lohmann C, Andreacchio D, Boyan BD, Schwartz Z. Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice. J Bone Joint Surg Am. 2007;89:139–47.CrossRefGoogle Scholar
  7. 7.
    Agrawal CM, Best J, Heckman JD, Boyan BD. Protein release kinetics of a biodegradable implant for fracture non-unions. Biomaterials. 1995;16(16):1255–60.CrossRefGoogle Scholar
  8. 8.
    Middleton John C, Tipton Arthur J. Synthetic biodegradable polymers as orthopedic devices. Biomaterials. 2000;21:2335–46.CrossRefGoogle Scholar
  9. 9.
    Ferdous Jahid, Kolachalama Vijaya B, Shazly Tarek. Impact of polymer structure and composition on fully resorbable endovascular scaffold performance. Acta Biomater. 2013;9:6052–61.CrossRefGoogle Scholar
  10. 10.
    Van den Dolder J, Mooren R, Vloon APG, Stoelinga PJ, Jansen JA. Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. Tissue Eng. 2006;12:3067–73. doi: 10.1089/ten.2006.12.3067.CrossRefGoogle Scholar
  11. 11.
    Arpornmaeklong P, Kochel M, Depprich R. Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. Int J Oral Maxillofac Surg. 2004;33:60–70. doi: 10.1016/j.ijom.2003.0492.CrossRefGoogle Scholar
  12. 12.
    Lana JFSD, Santana MHA, Belangero WD, Luzo ACM, editors. Platelet-rich plasma: regenerative medicine: sports medicine, orthopedic, and recovery of musculoskeletal injuries. Berlin: Springer; 2014.Google Scholar
  13. 13.
    Doğanavşargil B, Ayhan E, Argin M, Pehlivanoğlu B, Keçeci B, Sezak M, Başdemir G, Öztop F. Cystic bone lesions: histopathological spectrum and diagnostic challenges. Turk Patol Derg. 2015;31:95–103. doi: 10.5146/tjpath.2014.01293.Google Scholar
  14. 14.
    Arthrex. BioComposite interference screws for ACL and PCL reconstruction. Accessed 20 April 2015.

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Krzysztof Ficek
    • 1
    • 2
    • 3
    Email author
  • Jolanta Filipek
    • 1
  • Piotr Wojciechowski
    • 1
    • 4
  • Konrad Kopec
    • 1
    • 4
  • Stodolak-Zych Ewa
    • 5
  • Stanislaw Blazewicz
    • 5
  1. 1.Galen-OrthopaedicsBierunPoland
  2. 2.Department of Physical Culture and Health PromotionUniversity of SzczecinSzczecinPoland
  3. 3.Academy of Physical EducationKatowicePoland
  4. 4.Department of Orthopaedics and TraumatologyMedical University of Silesia, School of Medicine in KatowiceKatowicePoland
  5. 5.Department of Biomaterials, Faculty of Materials Science and CeramicsAGH University of Science and TechnologyKrakowPoland

Personalised recommendations