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3D fibre deposition and stereolithography techniques for the design of multifunctional nanocomposite magnetic scaffolds

  • Roberto De SantisEmail author
  • Ugo D’Amora
  • Teresa Russo
  • Alfredo Ronca
  • Antonio Gloria
  • Luigi Ambrosio
Special Issue: ESB 2015 Engineering and Nano-Engineering Approaches for Medical Devices
Part of the following topical collections:
  1. Special Issue: ESB 2015

Abstract

Magnetic nanocomposite scaffolds based on poly(ε-caprolactone) and poly(ethylene glycol) were fabricated by 3D fibre deposition modelling (FDM) and stereolithography techniques. In addition, hybrid coaxial and bilayer magnetic scaffolds were produced by combining such techniques. The aim of the current research was to analyse some structural and functional features of 3D magnetic scaffolds obtained by the 3D fibre deposition technique and by stereolithography as well as features of multimaterial scaffolds in the form of coaxial and bilayer structures obtained by the proper integration of such methods. The compressive mechanical behaviour of these scaffolds was investigated in a wet environment at 37 °C, and the morphological features were analysed through scanning electron microscopy (SEM) and X-ray micro-computed tomography. The capability of a magnetic scaffold to absorb magnetic nanoparticles (MNPs) in water solution was also assessed. confocal laser scanning microscopy was used to assess the in vitro biological behaviour of human mesenchymal stem cells (hMSCs) seeded on 3D structures. Results showed that a wide range of mechanical properties, covering those spanning hard and soft tissues, can be obtained by 3D FDM and stereolithography techniques. 3D virtual reconstruction and SEM showed the precision with which the scaffolds were fabricated, and a good-quality interface between poly(ε-caprolactone) and poly(ethylene glycol) based scaffolds was observed for bilayer and coaxial scaffolds. Magnetised scaffolds are capable of absorbing water solution of MNPs, and a preliminary information on cell adhesion and spreading of hMSCs was obtained without the application of an external magnetic field.

Keywords

Compressive Modulus Fuse Deposition Modelling Brazilian Test Porous Cylinder Neodymium Magnet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This research was partially supported by Project Grant PRIN 2010 - 2010L9SH3K_008.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Roberto De Santis
    • 1
    Email author
  • Ugo D’Amora
    • 1
  • Teresa Russo
    • 1
  • Alfredo Ronca
    • 1
  • Antonio Gloria
    • 1
  • Luigi Ambrosio
    • 2
  1. 1.Institute of Polymers, Composites and BiomaterialsNational Research Council of ItalyNaplesItaly
  2. 2.Department of Chemical Science and Materials TechnologyNational Research Council of ItalyRomeItaly

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