Oxygen diffusion in marine-derived tissue engineering scaffolds

  • E. Boccardi
  • I. V. Belova
  • G. E. Murch
  • A. R. Boccaccini
  • T. Fiedler
Tissue Engineering Constructs and Cell Substrates Original Research

DOI: 10.1007/s10856-015-5531-2

Cite this article as:
Boccardi, E., Belova, I.V., Murch, G.E. et al. J Mater Sci: Mater Med (2015) 26: 200. doi:10.1007/s10856-015-5531-2
Part of the following topical collections:
  1. Tissue Engineering Constructs and Cell Substrates

Abstract

This paper addresses the computation of the effective diffusivity in new bioactive glass (BG) based tissue engineering scaffolds. High diffusivities facilitate the supply of oxygen and nutrients to grown tissue as well as the rapid disposal of toxic waste products. The present study addresses required novel types of bone tissue engineering BG scaffolds that are derived from natural marine sponges. Using the foam replication method, the scaffold geometry is defined by the porous structure of Spongia Agaricina and Spongia Lamella. These sponges present the advantage of attaining scaffolds with higher mechanical properties (2–4 MPa) due to a decrease in porosity (68–76 %). The effective diffusivities of these structures are compared with that of conventional scaffolds based on polyurethane (PU) foam templates, characterised by high porosity (>90 %) and lower mechanical properties (>0.05 MPa). Both the spatial and directional variations of diffusivity are investigated. Furthermore, the effect of scaffold decomposition due to immersion in simulated body fluid (SBF) on the diffusivity is addressed. Scaffolds based on natural marine sponges are characterised by lower oxygen diffusivity due to their lower porosity compared with the PU replica foams, which should enable the best oxygen supply to newly formed bone according the numerical results. The oxygen diffusivity of these new BG scaffolds increases over time as a consequence of the degradation in SBF.

Funding information

Funder NameGrant NumberFunding Note
Australian Research Council
  • DP130101377
EU ITN FP-7 project
  • GlaCERCo

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Materials Science and Engineering, Institute of BiomaterialsUniversity of Erlangen-NurembergErlangenGermany
  2. 2.School of EngineeringUniversity of NewcastleCallaghanAustralia

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