Biomaterial science meets computational biology

Special Issue: ESB 2014 Biomaterials Synthesis and Characterisation
Part of the following topical collections:
  1. Special Issue: ESB 2014

Abstract

There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Faculty of Science and EngineeringQueensland University of TechnologyBrisbaneAustralia
  2. 2.Faculty of HealthQueensland University of TechnologyBrisbaneAustralia
  3. 3.Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia
  4. 4.Institute for Advanced StudyTechnical University of MunichMunichGermany
  5. 5.Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneAustralia
  6. 6.Translational Research InstituteBrisbaneAustralia

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