Biofabricated constructs as tissue models: a short review
- 521 Downloads
Biofabrication is currently able to provide reliable models for studying the development of cells and tissues into multiple environments. As the complexity of biofabricated constructs is becoming increasingly higher their ability to closely mimic native tissues and organs is also increasing. Various biofabrication technologies currently allow to precisely build cell/tissue constructs at multiple dimension ranges with great accuracy. Such technologies are also able to assemble together multiple types of cells and/or materials and generate constructs closely mimicking various types of tissues. Furthermore, the high degree of automation involved in these technologies enables the study of large arrays of testing conditions within increasingly smaller and automated devices both in vitro and in vivo. Despite not yet being able to generate constructs similar to complex tissues and organs, biofabrication is rapidly evolving in that direction. One major hurdle to be overcome in order for such level of complex detail to be achieved is the ability to generate complex vascular structures within biofabricated constructs. This review describes several of the most relevant technologies and methodologies currently utilized within biofabrication and provides as well a brief overview of their current and future potential applications.
KeywordsHuman Umbilical Vein Endothelial Cell Additive Manufacturing Inkjet Printer Selective Laser Sinter Fuse Deposition Modelling
Pedro F. Costa would like to thank the TUM University Foundation for his current Postdoctoral fellowship.
- 1.Project on Emerging Nanotechnologies. Consumer Products Inventory. Retrieved October 2013, from http://www.nanotechproject.org/cpi.
- 5.Brun P, Dickinson SC, Zavan B, Cortivo R, Hollander AP, Abatangelo G. Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation. Arthritis Res Ther. 2008;10(6):R132. doi: 10.1186/ar2549.CrossRefGoogle Scholar
- 7.Mason C. Automated tissue engineering: a major paradigm shift in health care. Med Device Technol. 2003;14(1):16–8.Google Scholar
- 51.Liebschner MAK, Chun K, Behni B. Intra-Operative Patient Specific Functional Scaffold Fabrication. Orthopaedic Research Society Annual Meeting; February; San Francisco (USA); 2012.Google Scholar