Interpenetrating polymer network hydrogel scaffolds for artificial cornea periphery

  • Rachel Parke-Houben
  • Courtney H. Fox
  • Luo Luo Zheng
  • Dale J. Waters
  • Jennifer R. Cochran
  • Christopher N. Ta
  • Curtis W. Frank
Clinical Applications of Biomaterials

DOI: 10.1007/s10856-015-5442-2

Cite this article as:
Parke-Houben, R., Fox, C.H., Zheng, L.L. et al. J Mater Sci: Mater Med (2015) 26: 107. doi:10.1007/s10856-015-5442-2
Part of the following topical collections:
  1. Clinical Applications of Biomaterials

Abstract

Three-dimensional scaffolds based on inverted colloidal crystals (ICCs) were fabricated from sequentially polymerized interpenetrating polymer network (IPN) hydrogels of poly(ethyleneglycol) and poly(acrylic acid). This high-strength, high-water-content IPN hydrogel may be suitable for use in an artificial cornea application. Development of a highly porous, biointegrable region at the periphery of the artificial cornea device is critical to long-term retention of the implant. The ICC fabrication technique produced scaffolds with well-controlled, tunable pore and channel dimensions. When surface functionalized with extracellular matrix proteins, corneal fibroblasts were successfully cultured on IPN hydrogel scaffolds, demonstrating the feasibility of these gels as materials for the artificial cornea porous periphery. Porous hydrogels with and without cells were visualized non-invasively in the hydrated state using variable-pressure scanning electron microscopy.

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Rachel Parke-Houben
    • 1
  • Courtney H. Fox
    • 1
  • Luo Luo Zheng
    • 2
  • Dale J. Waters
    • 1
  • Jennifer R. Cochran
    • 2
  • Christopher N. Ta
    • 3
  • Curtis W. Frank
    • 1
  1. 1.Department of Chemical EngineeringStanford UniversityStanfordUSA
  2. 2.Department of BioengineeringStanford UniversityStanfordUSA
  3. 3.Department of OphthalmologyStanford UniversityStanfordUSA

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