Magnesium with micro-arc oxidation coating and polymeric membrane: an in vitro study on microenvironment

Biomaterials Synthesis and Characterization
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  1. Biomaterials Synthesis and Characterization

Abstract

Numerous modification methods have been reported to enhance the corrosion resistance of magnesium with positive results. However, little attention has been paid on their impact on micro-environment, particularly the ion concentration and local pH value. In this study, two different coatings were prepared on magnesium, one with porous micro-arc oxidation (MAO) coating alone, and the other with additional polymer polyhydroxybutyrate (PHB) membrane using spinning technique. Their in vitro corrosional and biological behaviors were investigated and compared. Both coatings were found to reduce the degradation rate of magnesium, but an additionally deposited PHB membrane was superior to MAO-coated magnesium since it could produce a micro-environment with preferable local pH value and ion concentration for osteoblast proliferation. Our study suggests that micro-environment should be another critical issue in evaluation of a modification method for orthopaedic implants.

Keywords

Corrosion Resistance Simulated Body Fluid Coated Sample Average Pore Size PHBV 
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Notes

Acknowledgments

The authors gratefully acknowledge the financial support of National Basic Research Program of China (Grant No. 2012CB619100), the National Natural Science Foundation of China (Grant Nos. 21105029, 51102097, 51072057) and Special funding for university talent introduction of Guangdong Province (GX N).

References

  1. 1.
    Pietak A, Mahoney P, Dias GJ, Staiger MP. Bone-like matrix formation on magnesium and magnesium alloys. J Mater Sci Mater Med. 2008;19:407–15.CrossRefGoogle Scholar
  2. 2.
    Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Phys. 2009;80:157–62.Google Scholar
  3. 3.
    Witte F. The history of biodegradable magnesium implants: a review. Acta Biomater. 2010;6:1680–92.CrossRefGoogle Scholar
  4. 4.
    Song G, Hapugoda S. St John D. Degradation of the surface appearance of magnesium and its alloys in simulated atmospheric environments. Corros Sci. 2007;49:1245–65.CrossRefGoogle Scholar
  5. 5.
    Zhang MX, Shi YN, Sun H, Kelly PM. Surface alloying of Mg alloys after surface nanocrystallization. J Nanosci Nanotechnol. 2008;8:2724–8.CrossRefGoogle Scholar
  6. 6.
    Yang J, Cui F, Lee IS. Surface modifications of magnesium alloys for biomedical applications. Ann Biomed Eng. 2011;39:1857.CrossRefGoogle Scholar
  7. 7.
    Wong HM, Yeung KW, Lam KO, Tam V, Chu PK, Luk KD, Cheung KM. A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials. 2010;31:2084–96.CrossRefGoogle Scholar
  8. 8.
    Shen Y, Liu W, Wen C, Pan HB, Wang T, Darvell BW, Lu WW, Huang W. Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold. J Mater Chem. 2012;22:8662–70.CrossRefGoogle Scholar
  9. 9.
    Kaunitz JD, Yamaguchi DT. TNAP, TrAP, ecto-purinergic signaling, and bone remodeling. J Cell Biochem. 2008;105:655–62.CrossRefGoogle Scholar
  10. 10.
    Harada M, Udagawa N, Fukasawa K, Hiraoka B, Mogi M. Inorganic pyrophosphatase activity of purified bovine pulp alkaline phosphatase at physiological pH. J Dent Res. 1986;65:125–7.CrossRefGoogle Scholar
  11. 11.
    Shen Y, Liu W, Kai L, Pan HB, Peng S, Darvell BW, Huang W, Wen P, Deng L, Liu X, Lu WW, Chang J. Interfacial pH: a critical factor for osteoporotic bone regeneration. Langmuir. 2011;27:2701–8.CrossRefGoogle Scholar
  12. 12.
    Guo HF, An MZ. Growth of ceramic coatings on AZ91D magnesium alloys by micro-arc oxidation in aluminate–fluoride solutions and evaluation of corrosion resistance. Appl Surf Sci. 2005;246:229–38.CrossRefGoogle Scholar
  13. 13.
    Paul W, Sharma CP. Nanoceramic matrices: biomedical applications. Am J Biochem Biotechnol. 2006;2:41–8.CrossRefGoogle Scholar
  14. 14.
    Knowles JC, Mahmud FA, Hastings GW. Piezoelectric characteristics of a polyhydroxybutyrate-based composite. Clin Mater. 1991;8:155–8.CrossRefGoogle Scholar
  15. 15.
    Fukada E, Ando Y. Piezoelectric properties of poly-β-hydroxybutyrate and copolymers of β-hydroxybutyrate and β-hydroxyvalerate. Int J Biol Macromol. 1986;8:361–6.CrossRefGoogle Scholar
  16. 16.
    Miara B, Rohan E, Zidi M, Labat B. Piezomaterials for bone regeneration design—homogenization approach. J Mech Phys Solids. 2005;53:2529–56.CrossRefGoogle Scholar
  17. 17.
    American Society for Testing and Materials. ASTM-G31-72: standard practice for laboratory immersion corrosion testing of metals. In: Annual Book of ASTM Standards. Philadelphia, PA: American Society for Testing and Materials; 2004.Google Scholar
  18. 18.
    Serre CM, Papillard M, Chavassieux P, Voegel JC, Boivin G. Influence of magnesium substitution on a collagen-apatite biomaterial on the production of a calcifying matrix by human osteoblasts. J Biomed Mater Res. 1998;42:626–33.CrossRefGoogle Scholar
  19. 19.
    Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006;27:1728–34.CrossRefGoogle Scholar
  20. 20.
    Zreiqat H, Howlett CR, Zannettino A, Evans P, Schulze-Tanzil G, Knabe C, Shakibaei M. Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. J Biomed Mater Res. 2002;62:175–84.CrossRefGoogle Scholar
  21. 21.
    Gu X, Li N, Zhou W, Zheng Y, Zhao X, Cai Q, Ruan L. Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy. Acta Biomater. 2011;7:1880–9.CrossRefGoogle Scholar
  22. 22.
    Liu C, Xin Y, Tian X, Chu PK. Corrosion behavior of AZ91 magnesium alloy treated by plasma immersion ion implantation and deposition in artificial physiological fluids. Thin Solid Films. 2007;516:422–7.CrossRefGoogle Scholar
  23. 23.
    Hoche H, Scheerer H, Probst D, Broszeit E, Berger C. Plasma anodisation as an environmental harmless method for the corrosion protection of magnesium alloys. Surf Coat Technol. 2003;174:1002–7.CrossRefGoogle Scholar
  24. 24.
    Cui X, Yang Y, Liu E, Jin G, Zhong J, Li Q. Corrosion behaviors in physiological solution of cerium conversion coatings on AZ31 magnesium alloy. Appl Surf Sci. 2011;257:9703–9.CrossRefGoogle Scholar
  25. 25.
    Jamesh M, Kumar S, Narayanan S. Electrodeposition of hydroxyapatite coating on magnesium for biomedical applications. J Coat Technol Res. 2011;9:495–502.CrossRefGoogle Scholar
  26. 26.
    Guo M, Cao L, Lu P, Liu Y, Xu X. Anticorrosion and cytocompatibility behavior of MAO/PLLA modified magnesium alloy WE42. J Mater Sci Mater Med. 2011;22:1735–40.CrossRefGoogle Scholar
  27. 27.
    Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials. 2006;27:3413–31.CrossRefGoogle Scholar
  28. 28.
    Li H. Fabrication and characterization of bioactive wollastonite/PHBV composite scaffolds. Biomaterials. 2004;25:5473–80.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.School of Materials Science and EngineeringSouth China University of TechnologyGuangzhouChina
  2. 2.Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhenChina
  3. 3.Institute of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouChina
  4. 4.Department of Orthopaedics and Traumatology, Nanfang HospitalSouthern Medical UniversityGuangzhouChina

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