Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2627–2633 | Cite as

Regeneration of the limb: opinions on the reality

  • Eugene Yong-Shun See
  • Mangesh Kulkarni
  • Abhay PanditEmail author


Whenever the topic of re-growing human limbs is posed for discussion, it is often argued that ‘if a newt can do it, then so can we’. This notion, albeit promising, is somewhat like watching a science-fiction film; the individual components are currently available but we are far from realizing the complete picture. Today’s reality is that if we are faced with a limb-severing injury, any regenerative attempt would endeavour to accelerate the pace at which the tissue heals to a clinically relevant/functional state. The science of limb regeneration can be approached from three different angles, developmental biology; regenerative medicine; and tissue engineering. This opinion piece describes how each approach can be used to understand the concepts behind regeneration, how far each approach has advanced and the hurdles faced by each of the approaches.


Anterior Cruciate Ligament Tissue Engineering Anterior Cruciate Ligament Reconstruction Donor Site Morbidity Limb Regeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to acknowledge Prof. Joachim Kohn for stimulating this discussion. Dr. Uri Frank, Dr. Carolyn Holladay, Mohammad Aburub for helpful suggestions in formulating some of the discussions.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Eugene Yong-Shun See
    • 1
  • Mangesh Kulkarni
    • 1
  • Abhay Pandit
    • 1
    Email author
  1. 1.Network of Excellence for Functional Biomaterials (NFB)National University of IrelandGalwayIreland

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