Magnesium- and strontium-co-substituted hydroxyapatite: the effects of doped-ions on the structure and chemico-physical properties
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The present study is aimed at investigating the contribution of two biologically important cations, Mg2+ and Sr2+, when substituted into the structure of hydroxyapatite (Ca10(PO4)6(OH)2,HA). The substituted samples were synthesized by an aqueous precipitation method that involved the addition of Mg2+- and Sr2+-containing precursors to partially replace Ca2+ ions in the apatite structure. Eight substituted HA samples with different concentrations of single (only Mg2+) or combined (Mg2+ and Sr2+) substitution of cations have been investigated and the results compared with those of pure HA. The obtained materials were characterized by X-ray powder diffraction, specific surface area and porosity measurements (N2 adsorption at 77 K), FT-IR and Raman spectroscopies and scanning electron microscopy. The results indicate that the co-substitution gives rise to the formation of HA and β-TCP structure types, with a variation of their cell parameters and of the crystallinity degree of HA with varying levels of substitution. An evaluation of the amount of substituents allows us to design and prepare BCP composite materials with a desired HA/β-TCP ratio.
This work was financially supported by the Italian Ministry MUR (Project COFIN-2006, Prot. 2006032335_004: “Interface phenomena in silica-based nanostructured biocompatible materials contacted with biological systems”), by Regione Piemonte Italy (Project CIPE-2004: “Nanotechnologies and Nanosciences. Nanostructured materials biocompatible for biomedical applications”) and by San Paolo company Project Id: ORTO11RRT5, whose contribution is gratefully acknowledged. V.A. kindly acknowledges Regione Piemonte, Italy, for a postdoctoral fellowship. FEI acknowledges ERASMUS programme for financial support during her research study at the University of Torino.
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