Journal of Materials Science: Materials in Medicine

, Volume 23, Issue 11, pp 2783–2792 | Cite as

Transplantation of nano-bioglass/gelatin scaffold in a non-autogenous setting for bone regeneration in a rabbit ulna

  • Forough Hafezi
  • Fatemeh Hosseinnejad
  • Abbas Ali Imani Fooladi
  • Soroush Mohit Mafi
  • Afsaneh Amiri
  • Mohammad Reza NouraniEmail author


Bioactive glass has been investigated for variety of tissue engineering applications. In this study, fabrication, in vitro and in vivo evaluation of bioactive glass nanocomposite scaffold were investigated. The nanocomposite scaffolds with compositions based on gelatin and bioactive glass nanoparticles were prepared. The apatite formation at the surface of the nanocomposite samples confirmed by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray powder diffraction analyses. The in vitro characteristics of bioactive glass scaffold as well as the in vivo bone formation capacity of the bioactive glass scaffold in rabbit ulnar model were investigated. The bioactive glass scaffold showed no cytotoxicity effects in vitro. The nanocomposite scaffold made from gelatin and bioactive glass nanoparticles could be deliberated as an extremely bioactive and prospective bone tissue engineering implant. Bioactive glass scaffolds were capable of guiding bone formation in a rabbit ulnar critical-sized-defect model. Radiographic evaluation indicated that successful bridging of the critical-sized defect on the sides both next to and away from the radius took place using bioactive glass scaffolds. X-ray analysis also proposed that bioactive glass scaffolds supported normal bone formation via intramembranous formation


Bioactive Glass Bone Tissue Engineering Enrofloxacin Nanocomposite Sample Triethyl Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank many colleagues and collaborators specially Saied Maleknia, and Dr. Mahmoud Azami who have had an enormous role in this research. This work was supported by the grant from the Iranian National Sciences foundation (INSF) and Nano bio technology research center of Baqiyatallah Medical Sciences University.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Forough Hafezi
    • 2
  • Fatemeh Hosseinnejad
    • 2
  • Abbas Ali Imani Fooladi
    • 3
  • Soroush Mohit Mafi
    • 4
  • Afsaneh Amiri
    • 2
  • Mohammad Reza Nourani
    • 1
    Email author
  1. 1.Tissue Engineering Division, Chemical Injury Research CenterBaqiyatallah University of Medical SciencesTehranIran
  2. 2.Department of ChemistryIslamic Azad UniversityTehranIran
  3. 3.Applied Microbiology Research CenterBaqiyatallah University of Medical SciencesTehranIran
  4. 4.Department of VeterinaryIslamic Azad UniversityKarajIran

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