A novel antibacterial resin composite for improved dental restoratives

  • Yiming Weng
  • Leah Howard
  • Xia Guo
  • Voon Joe Chong
  • Richard L. Gregory
  • Dong XieEmail author


A novel furanone-containing antibacterial resin composite has been prepared and evaluated. compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. The modified resin composites showed a significant antibacterial activity without substantially decreasing the mechanical strengths. With 5–30 % addition of the furanone derivative, the composite kept its original CS unchanged but showed a significant antibacterial activity with a 16–68 % reduction in the S. mutans viability. Further, the antibacterial function of the new composite was not affected by human saliva. The aging study indicates that the composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that the experimental antibacterial resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.


Compressive Strength Flexural Strength Resin Composite Quaternary Ammonium Salt DMAEMA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was sponsored by NIH challenge grant (RC1) DE020614.


  1. 1.
    Mjor IA, Dahl JE, Moorhead JE. Placement and replacement of restorations in primary teeth. Acta Odontol Scand. 2002;60:25–8.CrossRefGoogle Scholar
  2. 2.
    Forss H, Widstrom E. Reasons for restorative therapy and longevity of restorations in adults. Acta Odontol Scand. 2004;62:82–6.CrossRefGoogle Scholar
  3. 3.
    Manhart J, Garcia-Godoy F, Hickel R. Direct posterior restorations: clinical results and new developments. Dent Clin North Am. 2002;46:303–39.CrossRefGoogle Scholar
  4. 4.
    Deligeorgi V, Mjor IA, Wilson NH. An overview of reasons for the placement and replacement of restorations. Prim Dent Care. 2001;8:5–11.CrossRefGoogle Scholar
  5. 5.
    Craig RG, Power JM. Restorative dental materials. 11th ed. St. Louis: Mosby-Year Book, Inc.; 2002. p. 614–8.Google Scholar
  6. 6.
    Wiegand A, Buchalla W, Attin T. Review on fluoride-releasing restorative materials—fluoride release and uptake characteristics, antibacterial activity and influence on caries formation. Dent Mater. 2007;23:343–62.CrossRefGoogle Scholar
  7. 7.
    Osinaga PW, Grande RH, Ballester RY, Simionato MR, Delgado Rodrigues CR, Muench A. Zinc sulfate addition to glass-ionomer-based cements: influence on physical and antibacterial properties, zinc and fluoride release. Dent Mater. 2003;19:212–7.CrossRefGoogle Scholar
  8. 8.
    Takahashi Y, Imazato S, Kaneshiro AV, Ebisu S, Frencken JE, Tay FR. Antibacterial effects and physical properties of glass-ionomer cements containing chlorhexidine for the ART approach. Dent Mater. 2006;22:647–52.CrossRefGoogle Scholar
  9. 9.
    Yamamoto K, Ohashi S, Aono M, Kokubo T, Yamada I, Yamauchi J. Antibacterial activity of silver ions implanted in SiO2 filler on oral Streptococci. Dent Mater. 1996;12:227–9.Google Scholar
  10. 10.
    Syafiuddin T, Hisamitsu H, Toko T, Igarashi T, Goto N, Fujishima A, Miyazaki T. In vitro inhibition of caries around a resin composite restoration containing antibacterial filler. Biomaterials. 1997;18:1051–7.CrossRefGoogle Scholar
  11. 11.
    Gottenbos B, van der Mei HC, Klatter F, Nieuwenhuis P, Busscher HJ. In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber. Biomaterials. 2002;23:1417–23.CrossRefGoogle Scholar
  12. 12.
    Thebault P, Taffin de Givenchy E, Levy R, Vandenberghe Y, Guittard F, Geribaldi S. Preparation and antimicrobial behaviour of quaternary ammonium thiol derivatives able to be grafted on metal surfaces. Eur J Med Chem. 2009;44:717–24.CrossRefGoogle Scholar
  13. 13.
    Imazato S, Russell RR, McCabe JF. Antibacterial activity of MDPB polymer incorporated in dental resin. J Dent. 1995;23:177–81.CrossRefGoogle Scholar
  14. 14.
    Murata H. Permanent, non-leaching antibacterial surfaces—2: how high density cationic surfaces kill bacterial cells. Biomaterials. 2007;28:4870–9.CrossRefGoogle Scholar
  15. 15.
    Guiqian Lu, Dingcai Wu, Ruowen Fu. Studies on the synthesis and antibacterial activities of polymeric quaternary ammonium salts from dimethylaminoethyl methacrylate. React Funct Polym. 2007;67:355–66.CrossRefGoogle Scholar
  16. 16.
    Lee SB, Koepsel RR, Morley SW, Matyjaszewski K, Sun Y, Russell AJ. Permanent, non-leaching antibacterial surfaces 1. Synthesis by atom transfer radical polymerization. Biomacromolecules. 2004;5:877–82.CrossRefGoogle Scholar
  17. 17.
    Li F, Chai ZG, Sun MN, Wang F, Ma S, Zhang L, Fang M, Chen JH. Anti-biofilm effect of dental adhesive with cationic monomer. J Dent Res. 2009;88:372–6.CrossRefGoogle Scholar
  18. 18.
    Li F, Chen J, Chai Z, Zhang L, Xiao Y, Fang M, Ma S. Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans. J Dent. 2009;37:289–96.CrossRefGoogle Scholar
  19. 19.
    Beyth N, Yudovin-Farber I, Bahir R, Domb AJ, Weiss EI. Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans. Biomaterials. 2006;27:3995–4002.CrossRefGoogle Scholar
  20. 20.
    Weng Y, Guo X, Chong VJ, Howard L, Gregory RL, Xie D. Synthesis and evaluation of a novel antibacterial dental resin composite with quaternary ammonium salts. J Biomater Sci Eng. 2011;4:147–57.CrossRefGoogle Scholar
  21. 21.
    Imazato S, Ebi N, Takahashi Y, Kaneko T, Ebisu S, Russell RRB. Antibacterial activity of bactericide-immobilized filler for resin-based restoratives. Biomaterials. 2003;24:3605–9.CrossRefGoogle Scholar
  22. 22.
    Ebi N, Imazato S, Noiri Y, Ebisu S. Inhibitory effects of resin composite containing bactericide-immobilized filler on plaque accumulation. Dent Mater. 2001;17:485–91.CrossRefGoogle Scholar
  23. 23.
    Jung JH, Pummangura S, Chaichantipyuth C, Patarapanich C, Fanwick PE, Chang CJ, Mclaughlin JL. New bioactive heptenes from Melodorum fruticosum (Annonaceae). Tetrahedron. 1990;46:5043–54.CrossRefGoogle Scholar
  24. 24.
    Jones JB, Young JM. Carcinogenicity of lactones III: the reactions of unsaturated 4-lactones with l-cysteine. J Med Chem. 1968;11:1176.CrossRefGoogle Scholar
  25. 25.
    Lattmann E, Dunn S, Niamsanit S, Sattayasai N. Synthesis and antibacterial activities of 5-hydroxy-4-amino-2(5H)-furanones. Bioorg Med Chem Lett. 2005;15:919–21.CrossRefGoogle Scholar
  26. 26.
    Xie D, Faddah M, Park J-G. Novel amino acid modified zinc polycarboxylates for improved dental cements. Dent Mater. 2005;21(8):739–48.CrossRefGoogle Scholar
  27. 27.
    Xie D, Feng F, Chung I-D, Eberhardt AW. A hybrid zinc–calcium–silicate polyalkenoate bone cement. Biomaterials. 2003;24(16):2749–57.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yiming Weng
    • 1
  • Leah Howard
    • 1
  • Xia Guo
    • 1
  • Voon Joe Chong
    • 1
  • Richard L. Gregory
    • 2
  • Dong Xie
    • 1
    Email author
  1. 1.Department of Biomedical Engineering, Purdue School of Engineering and TechnologyIndiana University–Purdue University at IndianapolisIndianapolisUSA
  2. 2.Department of Oral Biology, School of DentistryIndiana UniversityIndianapolisUSA

Personalised recommendations