A novel antibacterial resin composite for improved dental restoratives
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A novel furanone-containing antibacterial resin composite has been prepared and evaluated. compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. The modified resin composites showed a significant antibacterial activity without substantially decreasing the mechanical strengths. With 5–30 % addition of the furanone derivative, the composite kept its original CS unchanged but showed a significant antibacterial activity with a 16–68 % reduction in the S. mutans viability. Further, the antibacterial function of the new composite was not affected by human saliva. The aging study indicates that the composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that the experimental antibacterial resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.
KeywordsCompressive Strength Flexural Strength Resin Composite Quaternary Ammonium Salt DMAEMA
This work was sponsored by NIH challenge grant (RC1) DE020614.
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