The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation

  • Paul D. Thornton
  • Ruairi Brannigan
  • Joanna Podporska
  • Brid Quilty
  • Andreas Heise


A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-carboxyanhydride ring opening polymerisation is disclosed. Poly-l-glutamic acid and poly-l-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly-l-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing polymers that are commonly employed in contemporary medical devices.



We would like to thank Science Foundation Ireland (SFI) for funding this work (Award: 07/IN1/B1792).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Paul D. Thornton
    • 1
  • Ruairi Brannigan
    • 1
  • Joanna Podporska
    • 2
  • Brid Quilty
    • 3
  • Andreas Heise
    • 1
  1. 1.School of Chemical SciencesDublin City UniversityDublin 9Ireland
  2. 2.School of Mechanical and Manufacturing EngineeringDublin City UniversityDublin 9Ireland
  3. 3.School of BiotechnologyDublin City UniversityDublin 9Ireland

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