The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation
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A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-carboxyanhydride ring opening polymerisation is disclosed. Poly-l-glutamic acid and poly-l-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly-l-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing polymers that are commonly employed in contemporary medical devices.
We would like to thank Science Foundation Ireland (SFI) for funding this work (Award: 07/IN1/B1792).
- 4.Nazly Pirmoradi F, Jackson JK, Burt HM, Chiao M. On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device. Lab Chip, 2011; Advance Article. doi: 10.1039/C1LC20134D.
- 5.Kim S-J, Lee JK, Kim JW, Jung J-W, Seo K, Park S-B, Roh K-H, Lee S-R, Hong YH, Kim SJ, Lee Y-S, Kim SJ. Surface modification of polydimethylsiloxane (PDMS) induced proliferation and neural-like cells differentiation of umbilical cord blood-derived mesenchymal stem cells. J Mater Sci Mater Med. 2008;19:2953–62.CrossRefGoogle Scholar
- 12.Habraken GJM, Koning CE, Heuts JPA, Heise A. Thiol chemistry on well-defined synthetic polypeptides. Chem Commun. 2009;3612–3614.Google Scholar
- 27.Yamamoto Y, Hiraki J. Silicone-modified antimicrobial polymer, antimicrobial agent and antimicrobial resin composition. Patent # 7470753 B2, 2008.Google Scholar