Characterization of an antimicrobial dental resin adhesive containing zinc methacrylate

  • Sandrina Henn
  • Fernanda Nedel
  • Rodrigo Varella de Carvalho
  • Rafael Guerra Lund
  • Maximiliano Sérgio Cenci
  • Tatiana Pereira-Cenci
  • Flávio Fernando Demarco
  • Evandro Piva
Article

Abstract

This study evaluates the effect of zinc methacrylate (ZM) on the degree of conversion (DC), cytotoxicity and antimicrobial activity (AA) of an experimental resin. Tetraethyleneglycol dimethacrylate was used as the experimental resin and it was photo activated using camphoroquinone and ethyl 4-dimethylamine benzoate. Additionally, 1.0, 2.5, 5.0, 10, 20 and 30 wt% of ZM was added to the various experimental resins. The DC was accessed by Fourier Transform infrared spectroscopy. For cytotoxicity, immortalized mouse fibroblasts were exposed to the experimental resin extracts. An MTT assay was used to access the cytotoxicity. The AA against Streptococcus mutans UA159 was accessed by the agar diffusion method. An improvement in the DC in all concentrations of ZM was observed. The greater the amount of ZM on the experimental resin, the less the cytotoxicity was provoked. Three ZM concentrations showed AA that exhibited various inhibition growth zones with 10, 20 (10 mm) and 30 wt% (15 mm).

Notes

Acknowledgments

The authors were grateful to CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) for the scholarship and to Esstech, Inc. for the donation of the reagents and CNPq for financial support (Grant 306822/2008-3).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sandrina Henn
    • 1
  • Fernanda Nedel
    • 1
  • Rodrigo Varella de Carvalho
    • 2
  • Rafael Guerra Lund
    • 1
  • Maximiliano Sérgio Cenci
    • 1
  • Tatiana Pereira-Cenci
    • 1
  • Flávio Fernando Demarco
    • 1
  • Evandro Piva
    • 1
  1. 1.Department of Operative DentistryCDC-Bio, School of Dentistry, Federal University of PelotasPelotasBrazil
  2. 2.Department of Restorative DentistrySchool of Dentistry, University of North ParanaLondrinaBrazil

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