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Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate

  • Xavier Struillou
  • Hervé Boutigny
  • Zahi Badran
  • Borhane H. Fellah
  • Olivier Gauthier
  • Sophie Sourice
  • Paul Pilet
  • Thierry Rouillon
  • Pierre Layrolle
  • Pierre Weiss
  • Assem Soueidan
Article

Abstract

An injectable composite silanized hydroxypropyl methyl cellulose/biphasic calcium phosphate (Si-HPMC/BCP) has been investigated in humans with promising results. The aim of this study was to evaluate his efficacy for treating periodontal defects (canine fenestration and premolar furcation) in dog models. At 3 months, we observed that bone formation around BCP particles in furcation model is more discernible but not statistically significant in defects filled with Si-HPMC/BCP compared to healing in control. We suggest that BCP particles sustain the bone healing process by osteoconduction, while the Si-HPMC hydrogel enhances intergranular cohesion and acts as an exclusion barrier. Furthermore, bone ingrowth is not so distinctive in superficial defects where the biomaterial appears unstable. These results with Si-HPMC/BCP are encouraging. In addition, this biomaterial is easy to use and simplifies the process of filling periodontal lesions. However, more researches are needed to improve the viscosity and hardness to adjust the material to the specificities of periodontal defects.

Keywords

Inductively Couple Plasma Atomic Emission Spectroscopy Bone Ingrowth Biphasic Calcium Phosphate Enamel Matrix Derivative Guide Tissue Regeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Xavier Struillou
    • 1
  • Hervé Boutigny
    • 2
  • Zahi Badran
    • 1
    • 2
  • Borhane H. Fellah
    • 3
  • Olivier Gauthier
    • 3
  • Sophie Sourice
    • 1
  • Paul Pilet
    • 1
  • Thierry Rouillon
    • 1
  • Pierre Layrolle
    • 5
  • Pierre Weiss
    • 1
  • Assem Soueidan
    • 1
    • 2
    • 4
  1. 1.INSERM, U791, Laboratory for Osteo-Articular and Dental Tissue Engineering (LIOAD), Faculty of Dental SurgeryUniversity of NantesNantesFrance
  2. 2.Department of Periodontology, Faculty of Dental SurgeryUniversity of NantesNantesFrance
  3. 3.Experimental SurgeryNational Veterinary School of NantesRoute de GachetFrance
  4. 4.ERT 2004University of NantesNantesFrance
  5. 5.INSERM, U957, LPRO, Faculty of MedicineUniversity of NantesNantesFrance

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