Formation and properties of magnesium–ammonium–phosphate hexahydrate biocements in the Ca–Mg–PO4 system

  • Elke Vorndran
  • Andrea Ewald
  • Frank A. Müller
  • Katharina Zorn
  • Andreas Kufner
  • Uwe Gbureck
Article

Abstract

Calcium substituted trimagnesium phosphate with the general formula CaxMg(3−x)(PO4)2 (0 < x < 1.5) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with 3.5 M diammonium hydrogenphosphate solution to form a cementitious matrix of magnesium ammonium phosphate hexahydrate (struvite). The degree of ionic substitution was shown to influence physical cement properties; clinically suitable cement formulations with setting times in the range 5–15 min and compressive strengths of >50 MPa were obtained for x ≤ 0.75 together with a grinding time ≥1 h and a powder to liquid ratio ≥2.5 g/ml. The cement cytocompatibility was investigated by culturing human osteoblast cell line MG63 on cement surfaces demonstrating pronounced cell growth during 13 days cultivation.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Elke Vorndran
    • 1
  • Andrea Ewald
    • 1
  • Frank A. Müller
    • 2
  • Katharina Zorn
    • 2
  • Andreas Kufner
    • 1
  • Uwe Gbureck
    • 1
  1. 1.Department for Functional Materials in Medicine and DentistryUniversity of WürzburgWürzburgGermany
  2. 2.Institute of Materials Science and Technology (IMT)Friedrich-Schiller-University of JenaJenaGermany

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